Mechanical and thermal anti-nociception in rats after systemic administration of verapamil
| Autor: | Slobodan M. Todorovic, Vesna Jevtovic-Todorovic, Sriyani Pathirathna, Adam Meyenburg |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Hot Temperature Calcium Channels L-Type Rats Sprague-Dawley Internal medicine medicine Animals L-type calcium channel Channel blocker Pain transmission Pain Measurement Analgesics Dose-Response Relationship Drug business.industry General Neuroscience Anti nociception Blockade Rats Endocrinology Nociception Verapamil Touch Systemic administration Female business medicine.drug |
| Zdroj: | Neuroscience letters. 360(1-2) |
| ISSN: | 0304-3940 |
| Popis: | Voltage-gated Ca2+ channels expressed in neurons may contribute to nociceptive information processing. However, the role of L-type Ca2+ channels in pain transmission is not well understood. In this study, we examined the effects of systemically administered verapamil, an antihypertensive agent and L-type Ca2+ channel blocker, on mechanical and thermal withdrawal thresholds in rats. Intraperitoneal injections of verapamil induced dose-dependent (3–18 mg/kg) mechanical and thermal anti-nociception in adult rats without altering their sensorimotor abilities. Our data suggest that L-type Ca2+ channels contribute to acute nociceptive signaling and that anti-nociceptive effects may result from the blockade of these channels. |
| Databáze: | OpenAIRE |
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