Mapping hippocampal and ventricular change in Alzheimer disease
| Autor: | David Gravano, Stephen E. Rose, Arthur W. Toga, Paul M. Thompson, Andrew L. Janke, Kiralee M. Hayashi, Michael S. Hong, David M. Doddrell, David H. Herman, Greig I. de Zubicaray, James Semple |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cognitive Neuroscience Hippocampus Hippocampal formation Corpus callosum Brain mapping Cerebral Ventricles Imaging Three-Dimensional Atrophy Neuroimaging Alzheimer Disease Internal medicine Image Processing Computer-Assisted medicine Humans Computer Simulation Longitudinal Studies Cognitive decline Mathematical Computing Aged Brain Mapping Middle Aged medicine.disease Entorhinal cortex Magnetic Resonance Imaging Neurology Disease Progression Cardiology Female Psychology |
| Zdroj: | NeuroImage. 22:1754-1766 |
| ISSN: | 1053-8119 |
| Popis: | We developed an anatomical mapping technique to detect hippocampal and ventricular changes in Alzheimer disease (AD). The resulting maps are sensitive to longitudinal changes in brain structure as the disease progresses. An anatomical surface modeling approach was combined with surface-based statistics to visualize the region and rate of atrophy in serial MRI scans and isolate where these changes link with cognitive decline. Sixty-two [corrected] high-resolution MRI scans were acquired from 12 AD patients (mean [corrected] age +/- SE at first scan: 68.7 +/- 1.7 [corrected] years) and 14 matched controls (age: 71.4 +/- 0.9 years) [corrected] each scanned twice (1.9 +/- 0.2 [corrected] years apart, when all subjects are pooled [corrected] 3D parametric mesh models of the hippocampus and temporal horns were created in sequential scans and averaged across subjects to identify systematic patterns of atrophy. As an index of radial atrophy, 3D distance fields were generated relating each anatomical surface point to a medial curve threading down the medial axis of each structure. Hippocampal atrophic rates and ventricular expansion were assessed statistically using surface-based permutation testing and were faster in AD than in controls. Using color-coded maps and video sequences, these changes were visualized as they progressed anatomically over time. Additional maps localized regions where atrophic changes linked with cognitive decline. Temporal horn expansion maps were more sensitive to AD progression than maps of hippocampal atrophy, but both maps correlated with clinical deterioration. These quantitative, dynamic visualizations of hippocampal atrophy and ventricular expansion rates in aging and AD may provide a promising measure to track AD progression in drug trials. |
| Databáze: | OpenAIRE |
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