A clinicopathological study of surgically resected lung cancer in patients with usual interstitial pneumonia
| Autor: | Nobuyuki Koyama, Yasutaka Watanabe, Eishin Hoshi, Yoshinori Kawabata, Shinichiro Koyama, Noboru Takayanagi, Tomohiko Ikeya |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms Gastroenterology 03 medical and health sciences 0302 clinical medicine Usual interstitial pneumonia Internal medicine medicine Humans In patient Lung cancer Lung Pathological Aged Retrospective Studies Aged 80 and over business.industry Smoking Histology Middle Aged respiratory system medicine.disease Idiopathic Pulmonary Fibrosis Surgery Normal group medicine.anatomical_structure 030228 respiratory system 030220 oncology & carcinogenesis Concomitant Carcinoma Squamous Cell Female business |
| Zdroj: | Respiratory Medicine. 129:158-163 |
| ISSN: | 0954-6111 |
| DOI: | 10.1016/j.rmed.2017.06.015 |
| Popis: | Background The clinicopathological characteristics of lung cancer with concomitant usual interstitial pneumonia (UIP) are insufficiently understood. This study aimed to elucidate a characteristic pathological feature of lung cancer that develops in patients with UIP, with a focus on the location of its onset. Methods We reviewed surgically obtained specimens, including 547 tumors from 526 patients who underwent lobectomy for lung cancer. Surveyed patients were classified into three groups: patients with UIP (UIP group), patients with lung pathology other than UIP (non-UIP group), and patients without any associated lung pathology (normal group). The histology as well as the lobe and location of the onset of lung cancer were compared among these groups. The peripheral location was subdivided into subpleural, inner and tumor involved centrally secondary to extension. Results The UIP group comprised 82 patients (male, 71 [87%]; mean age, 71 years; smoking rate, 94%), the non-UIP group comprised 334 patients (male, 267 [80%]; mean age, 69 years; smoking rate, 81%), and the normal group comprised 110 patients (male, 33 [30%]; mean age, 63; smoking rate, 29%). No statistical differences were noted in sex, mean age, or smoking index between the UIP and non-UIP groups. Compared with the non-UIP group, the frequency of squamous cell carcinoma (63% vs. 32%), lower lobe origin (76% vs. 32%), and subpleural location (24% vs. 5%) were significantly higher in the UIP group. Conclusions Lung cancers in patients with UIP show a predilection for the subpleural region, where UIP is also thought to originate. |
| Databáze: | OpenAIRE |
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