Some of the amino acid chemistry going on in the Laboratory of Amino Acids, Peptides and Proteins
| Autor: | Jean-Alain Fehrentz, N. Mai, J.-L. Aubagnac, Bérengère Sauvagnat, Valérie Rolland, Catherine Pothion, M. L. Roumestant, José Luis Martínez, M. Sadoune, Monique Calmes, J. Daunis, Ph. Viallefont, Y. Vidal, Frédéric Lamaty, Muriel Amblard, René Lazaro, Marielle Paris, Jean-Pierre Lavergne, C. Drouot, Farhate Guenoun, S. Bouifraden, M. El Hadrami, L. Lecointe, P. Chevallet, Christine Enjalbal |
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| Přispěvatelé: | Laboratoire des Amino-acides Peptides et Protéines (LAPP), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 1999 |
| Předmět: |
Peptide Biosynthesis
Clinical Biochemistry Ketene 010402 general chemistry Mass spectrometry Proteomics 01 natural sciences Biochemistry chemistry.chemical_compound Organic chemistry Reactivity (chemistry) Amino Acids ComputingMilieux_MISCELLANEOUS Schiff Bases chemistry.chemical_classification Chiral auxiliary [CHIM.ORGA]Chemical Sciences/Organic chemistry 010405 organic chemistry Chemistry Organic Chemistry Glycopeptides Proteins Stereoisomerism 0104 chemical sciences Amino acid Glycine Stereoselectivity Laboratories Peptides |
| Zdroj: | Amino Acids Amino Acids, Springer Verlag, 1999, 16, pp.345-379 HAL |
| ISSN: | 0939-4451 1438-2199 |
| Popis: | Some of the chemistry of amino acids going on in our laboratory (Laboratoire des Amino acides Peptides et Protéines) is described as well as some mass spectrometry methodology for their characterization particularly on solid supports. Several aspects are presented including: (i) the stereoselective synthesis of natural and unnatural amino acids using 2-hydroxypinan-3-one as chiral auxiliary; (ii) the stereoselective synthesis of natural and unnatural amino acids by deracemization of alpha-amino acids via their ketene derivatives; (iii) the synthesis of alpha-aryl-alpha-amino acids via reaction of organometallics with a glycine cation; (iv) the diastereoselective synthesis of glycosyl-alpha-amino acids; (v) the synthesis of beta-amino acids using alpha-aminopyrrolidinopiperazinediones as chiral templates; (vi) the reactivity of urethane-N-protected N-carboxyanhydrides. To characterize natural and non natural amino acids through their immonium ions by mass spectrometry, some methodology is also described. |
| Databáze: | OpenAIRE |
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