From water to aquaretics: a legendary route
| Autor: | Antonio Lacquaniti, Valentina Donato, Rosaria Lupica, Domenico Trimboli, Valeria Cernaro, Antoine Buemi, Michele Buemi, Giuseppina Lorenzano |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Vasopressin Physiology Aquaporin Biology Aquaporins Osmolarity lcsh:Physiology lcsh:Biochemistry Renin-Angiotensin System Osmoregulation Internal medicine Renin–angiotensin system medicine Animals Homeostasis Humans lcsh:QD415-436 Water transport lcsh:QP1-981 Osmotic concentration Water Cell biology Endocrinology Aquaretics Flux (metabolism) |
| Zdroj: | Cellular Physiology and Biochemistry, Vol 33, Iss 5, Pp 1369-1388 (2014) |
| ISSN: | 1421-9778 |
| Popis: | Man is water. When life appeared on earth, the primordial cell had a simple structure and could immediately ascertain from the surrounding aquatic environment the substances for nutrition and oxygen, without any need for structural complexity. As part of evolution, during the transition from aquatic to terrestrial life, vertebrates had to fight against dehydration as well as fish in the sea. In this complex mechanism of osmoregulation, the structure and function of some osmoregulatory hormones have been maintained during the evolution of species, from fish to man. Within the homeostatic mechanism, the renin-angiotensin-aldosterone system (RAAS) is crucial in the regulation of renal reasorption of water and sodium. It is also involved in the regulation of renal plasma flux, blood volume and blood pressure. Vasopressin plays a hormonal function in the mechanisms of water homeostasis acting through Aquaporins (AQP), channel-proteins that allow bi-directional water transport across cell membranes. |
| Databáze: | OpenAIRE |
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