Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine 'Goreisan'
| Autor: | Akihiko Kawana, Yohei Maki, Nobuyoshi Hayashi, Jun Miyata, Yuji Fujikura, Yoichi Tagami, Takayuki Yamamoto, Tomoya Sano, Chie Watanabe, Shinichiro Ota, Yosuke Okada, Hisashi Sasaki, Hiraku Ogata, Yoshifumi Kimizuka |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Water flow Dasatinib Antineoplastic Agents Case Report 030204 cardiovascular system & hematology Chylothorax 03 medical and health sciences 0302 clinical medicine Refractory chronic myeloid leukemia Leukemia Myelogenous Chronic BCR-ABL Positive hemic and lymphatic diseases Internal Medicine Humans Medicine Effective treatment Goreisan Intensive care medicine Adverse effect Aged Aged 80 and over Plant Extracts business.industry Myeloid leukemia General Medicine Middle Aged medicine.disease Pleural Effusion aquaporin Female Radiography Thoracic 030211 gastroenterology & hepatology Medicine Kampo business Phytotherapy medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, except for steroids. To the best of our knowledge, this is the first case of dasatinib-related chylothorax which was successfully controlled by combining diuretics with the Japanese herbal medicine “Goreisan.” “Goreisan” is known to inhibit aquaporin channels and regulate the water flow. Our findings showed that “Goreisan” is an effective treatment option for uncontrollable dasatinib-related chylothorax. |
| Databáze: | OpenAIRE |
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