Intracytoplasmic sperm injection with assisted oocyte activation resulting in successful pregnancies and live birth in couples with globozoospermia: A report of two cases
Autor: | Puneet Kaur Kochhar, Pranay Ghosh |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Pregnancy test medicine.medical_treatment intracytoplasmic sperm injection Case Report globozoospermia lcsh:Gynecology and obstetrics Intracytoplasmic sperm injection male infertility Andrology 03 medical and health sciences 0302 clinical medicine medicine Globozoospermia reproductive and urinary physiology lcsh:RG1-991 failed fertilization Pregnancy 030219 obstetrics & reproductive medicine business.industry urogenital system Oocyte activation assisted oocyte activation Oocyte medicine.disease Embryo transfer Pregnancy rate 030104 developmental biology medicine.anatomical_structure Reproductive Medicine embryonic structures business Acrosome |
Zdroj: | Journal of Human Reproductive Sciences, Vol 11, Iss 1, Pp 72-74 (2018) Journal of Human Reproductive Sciences |
ISSN: | 1998-4766 0974-1208 |
Popis: | Globozoospermia, characterized by round-headed acrosomeless sperm, is a rare and severe form of teratozoospermia. We report a successful pregnancy in two cases of total globozoospermia after intracytoplasmic sperm injection (ICSI) with oocyte activation with calcium ionophore. In the first case, globozoospermia was diagnosed on the day of oocyte retrieval. Among 11 retrieved oocytes, only one fertilized after ICSI. The pregnancy test 2 weeks after embryo transfer was negative. Two months later, the patient underwent ovarian stimulation again. The 12 retrieved oocytes were exposed to calcium ionophore medium following ICSI. Four oocytes were fertilized and two blastocysts were transferred resulting in a clinical pregnancy. In the second case, among seven retrieved oocytes, three fertilized after ICSI and assisted oocyte activation, and two 8-cell embryos were transferred, resulting in a positive pregnancy. The successful outcome here justifies the use of ICSI with oocyte activation to improve the pregnancy rate significantly when dealing with globozoospermia. |
Databáze: | OpenAIRE |
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