EXTRA NODAL SPREAD OF HODGKIN’S DISEASE
| Autor: | Mortimer R. Camiel, Antonio Medina, David L. Benninghoff |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Lung Adolescent business.industry medicine.medical_treatment Bone Neoplasms General Medicine Disease Pathogenesis medicine.anatomical_structure Lymphatic system medicine Humans Radiology Nuclear Medicine and imaging Extra nodal Lymph Embolization NODAL business Aged |
| Zdroj: | American Journal of Roentgenology. 111:368-375 |
| ISSN: | 1546-3141 0361-803X |
| DOI: | 10.2214/ajr.111.2.368 |
| Popis: | The pathogenesis of 45 instances of extra nodal Hodgkin’s disease occurring at 4 selected sites, the skin, epidura, lung, and bone, was studied in 150 patients. The corresponding regional lymph nodes were involved before the appearance of extra nodal disease in 75 per cent of these patients. In 40 per cent of the cases there was no evidence of other extra nodal disease. Retrograde lymphatic embolization of Hodgkin’s tumor cells was postulated as the mechanism of extra nodal spread.The major significance of these findings is that they emphasize the role of lymphatics in the spread of Hodgkin’s disease. Extension via lymphatics is probably the predominant mechanism of both inter nodal and extra nodal spread.The clinical data also suggest the importance of retrograde flow in lymphatics, a direction of flow that may occur in both inter nodal and extra nodal spread.Once the concept that extra nodal spread may occur by retrograde lymphatic embolization is accepted, then the implication of extra nodal disease fo... |
| Databáze: | OpenAIRE |
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