Cognitive and neurochemical alterations in hyperhomocysteinemic rat
| Autor: | Xiao-Ning Zeng, Ying Wu, Lin Gao, Rong-Ke Di, Hong-Ming Guo, Hui-Juan Chen, Xu-Ming Wu |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Hyperhomocysteinemia Serotonin Dopamine Prefrontal Cortex Dermatology Hippocampus Rats Sprague-Dawley chemistry.chemical_compound Neurochemical Cognition Neurotrophic factors Internal medicine medicine Animals Vascular dementia Neurotransmitter Maze Learning Homocysteine Brain-Derived Neurotrophic Factor Homovanillic Acid General Medicine Hydroxyindoleacetic Acid medicine.disease Rats Psychiatry and Mental health Endocrinology Monoamine neurotransmitter chemistry 3 4-Dihydroxyphenylacetic Acid Neurology (clinical) Psychology Neuroscience medicine.drug |
| Zdroj: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 33(1) |
| ISSN: | 1590-3478 |
| Popis: | Accumulating data have shown that the level of serum homocysteine in patients with mild cognitive impairment, vascular dementia and Alzheimer’s disease is higher than normal while the underlying mechanism is not fully understood. Here, a hyperhomocysteinemic rat model was made by maintaining rats on a diet high in methionine. The cognitive behavior, level of monoamine neurotransmitters in brain homogenates and brain-derived neurotrophic factor (BDNF) in cerebral spinal fluid (CSF) were compared between high-methionine diet and control group. The high-methionine diet group presented longer mean latency of escape and lesser time in target quadrant in morris maze test, lower level of serotonin and dopamine in cortex homogenates and lower level of BDNF in CSF. Together, our findings provide evidence that hyperhomocysteinemia could cause alterations of monoamine and neurotrophic factor, which might be further pathogenetic mechanisms underlying the cognitive deterioration. |
| Databáze: | OpenAIRE |
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