Patients with Takayasu's arteritis having persistent acute-phase response usually have an increased major vessel uptake by 18F-FDG-PET/CT
| Autor: | H. Turgut Turoglu, Fuat Dede, Fatma Alibaz-Oner, Haner Direskeneli, Tunc Ones |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Disease duration Takayasu's arteritis Computed tomography Blood Sedimentation Rheumatology Fluorodeoxyglucose F18 Active disease medicine Humans Arteritis Acute-Phase Reaction medicine.diagnostic_test business.industry Acute-phase protein Mean age medicine.disease Takayasu Arteritis C-Reactive Protein Positron-Emission Tomography Blood Vessels Female Fdg pet ct Radiology Radiopharmaceuticals Tomography X-Ray Computed business Nuclear medicine |
| Zdroj: | Modern Rheumatology. 25:752-755 |
| ISSN: | 1439-7609 1439-7595 |
| DOI: | 10.3109/14397595.2015.1012798 |
| Popis: | Although not uniformly accepted, an increased uptake by 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in large vessels is accepted to be a sign of active disease in Takayasu's arteritis (TAK). We aimed to investigate the value of 18F-FDG-PET/CT for clinical assessment in a subset of TAK patients having a persistent acute-phase response (APR) without any signs or symptoms of clinical disease activity.We studied 14 patients (mean age: 38.6 ± 13.9 years, Female/Male: 11/3, and disease duration: 5.7 ± 5 years). Patients were clinically inactive (according to the definition of activity by Kerr et al.), while categorized as having "persistent" disease activity by physician's global assessment due only to APR. 18F-FDG uptake was graded using a four-point scale from grade 0 (no uptake present) to grade 3 (high grade: uptake higher than that of liver). Any uptake in major vessels with a grade ≥ 2 was accepted to be "active."Mean erythrocyte sedimentation rate was 50.8 ± 13.2 mm/hour and mean C-reactive protein level was 28.5 ± 22.1 mg/L. Active vasculitic lesions were observed by 18F-FDG-PET/CT in 9 of 14 (64.3%) patients. The median number of active vascular lesions was 2 (range: 1-5). A step-up treatment change was decided in 8 patients according to 18F-FDG-PET/CT results.We observed increased 18F-FDG uptake in the majority of TAK patients with an increased APR, but clinically silent disease. 18F-FDG-PET/CT showed the presence and localization of active inflammation in the aorta and its branches. Although specificity for observed lesions is not clear, 18F-FDG-PET/CT imaging may influence physician's assessment of clinical activity and treatment choices in TAK. |
| Databáze: | OpenAIRE |
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