RETRACTED: Inhibition of miR-140-3p or miR-155-5p by antagomir treatment sensitize chordoma cells to chemotherapy drug treatment by increasing PTEN expression
| Autor: | Zefeng Niu, Qing Ruan, Fei Yin, Xinxin Chen, Kunchi Zhao, Jidong Xia, Xuefeng Li, Qingsan Zhu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Epithelial-Mesenchymal Transition medicine.medical_treatment Down-Regulation Antineoplastic Agents miR-155 Phosphatidylinositol 3-Kinases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Chordoma Humans Medicine PTEN Antagomir Neoplasm Metastasis Pharmacology Chemotherapy biology business.industry TOR Serine-Threonine Kinases PTEN Phosphohydrolase Antagomirs Drug Synergism medicine.disease Up-Regulation Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology chemistry Chemotherapy Drugs Cancer research biology.protein business Proto-Oncogene Proteins c-akt 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | European Journal of Pharmacology. 854:298-306 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2019.03.034 |
| Popis: | This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the authors and the Editor-in-Chief as the validity of the data cannot be guaranteed. The journal was initially contacted by the corresponding author to report that, when the authors verified post publication PTEN as their former target of miR-140-3p, they found that treatment with miR-140-3p or miR-155-5p antagomir increased PTEN protein levels in patient-derived chordoma cells without having a significant effect on the malignancy of the tumor cells. The journal further requested the author to provide more information about their post publication findings with regard to this article. However, the author was not able to fulfil this request. |
| Databáze: | OpenAIRE |
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