Shifting from constant-voltage to constant-current in Parkinson’s disease patients with chronic stimulation
| Autor: | Marcello Mario Mascia, Alberto Albanese, Angelo Franzini, Paolo Amami, F Saba |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease Neurology Deep brain stimulation medicine.medical_treatment 030508 substance abuse Stimulation Dermatology Neuropsychological Tests Subthalamic nucleus Statistics Nonparametric Executive functions 03 medical and health sciences 0302 clinical medicine Constant current Parkinson’s disease Internal medicine medicine Humans Prospective Studies Adverse effect Parkinson Disease General Medicine medicine.disease Inhibition Psychological Settore MED/26 - NEUROLOGIA Psychiatry and Mental health Physical therapy Cardiology Female Neurology (clinical) Neurosurgery 0305 other medical science Psychology 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Neurological Sciences. 38:1505-1508 |
| ISSN: | 1590-3478 1590-1874 |
| Popis: | The study aimed to evaluate safety and efficacy of shifting stimulation settings from constant-voltage (CV) to constant-current (CC) programming in patients with Parkinson's disease (PD) and chronic subthalamic nucleus deep brain stimulation (STN DBS). Twenty PD patients with chronic STN DBS set in CV programming were shifted to CC and followed for 3 months; the other stimulation settings and the medication regimen remained unchanged. Side effects, motor, non-motor, executive functions, and impedance were assessed at baseline and during follow-up. No adverse events were observed at time of shifting or during CC stimulation. Motor and non-motor measures remained unchanged at follow-up despite impedance decreased. Compared to baseline, inhibition processes improved at follow-up. The shifting strategy was well tolerated and the clinical outcome was maintained with no need to adjust stimulation settings or medications notwithstanding a decrease of impedance. Improvement of inhibition processes is a finding which needed further investigation. |
| Databáze: | OpenAIRE |
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