Phytoestrogen tissue levels in benign prostatic hyperplasia and prostate cancer and their association with prostatic diseases
| Autor: | Clemens Brössner, Klaus Fink, Peter Rehak, Marco Auprich, Karin Petritsch, Herman Adlercreutz, Stephan Madersbacher, P. H. Petritsch |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Nephrology medicine.medical_specialty Urology Prostatic Hyperplasia Genistein Phytoestrogens Adenocarcinoma Prostatic Diseases urologic and male genital diseases Lignans Pathogenesis 03 medical and health sciences chemistry.chemical_compound Prostate cancer 0302 clinical medicine 4-Butyrolactone Enterolactone Prostate Internal medicine medicine Humans Aged 030304 developmental biology Aged 80 and over 0303 health sciences urogenital system business.industry Prostatic Neoplasms Organ Size Middle Aged Hyperplasia medicine.disease Diet 3. Good health medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis business |
| Zdroj: | Urology. 64:707-711 |
| ISSN: | 0090-4295 |
| Popis: | Objectives. To compare phytoestrogen tissue levels in men with small-volume benign prostatic hyperplasia (BPH), large-volume BPH, and prostate cancer (PCa). Methods Prostatic tissue samples of men consuming a Western diet who underwent surgery for BPH (n = 63) or PCa (n = 31) were collected and frozen at −40°C. In the tissue samples, the enterolactone and genistein levels were determined in duplicate by monoclonal antibody-based immunoassays. We subsequently compared the tissue levels in patients with BPH and PCa and studied the impact of enterolactone and genistein on prostate volume. Results The enterolactone tissue levels were comparable in patients with BPH and PCa and revealed no correlation to prostate volume. The genistein tissue levels tended to be lower in patients with PCa (median 8.4 ng/g dry weight) compared with the entire BPH group (11.0 ng/g dry weight; P = 0.072). In addition, the genistein tissue levels were significantly greater in men with small-volume BPH (median 20.9 ng/g dry weight) compared with those with large-volume BPH (8.8 ng/g dry weight; P = 0.023). Conclusions Our data suggest an involvement of genistein in the pathogenesis of BPH and, possibly, of PCa. The impact of enterolactone is currently unknown. |
| Databáze: | OpenAIRE |
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