Identification of a missense variant in the porcine AGPAT gene family associated with intramuscular fat content through whole‐genome sequencing

Autor:	Joan Estany, Eduard Molinero García, Romi Pena, Roger Ros-Freixedes
Rok vydání:	2022
Předmět:	Mammals Pig Whole-genome sequencing Swine Fatty Acids Intramuscular fat General Medicine Backfat thickness Association study AGPAT5 Phenotype Adipose Tissue Fatty Acids Unsaturated Genetics Animals Animal Science and Zoology Fatty acids Muscle Skeletal
Zdroj:	Repositorio Abierto de la UdL Universitad de Lleida
ISSN:	1365-2052 0268-9146
DOI:	10.1111/age.13258
Popis:	The 1-acylglycerol-3-phosphate O-acyltransferases (AGPATs) are enzymes that catalyze the conversion of lysophosphatidic acid to phosphatidic acid, which is a precursor of triacylglycerol, the main fat reservoir in mammals. We used whole-genome sequencing of 205 pigs to identify 6639 genetic variants in the porcine AGPAT gene family. Of these, 166 common variants in the AGPAT5 gene had significant associations with fat content and composition traits. We preselected a missense single nucleotide polymorphism in exon 6 of AGPAT5 (rs196952262, A>G) for validation of its associations in 1034 pigs from the same Duroc line. The A allele showed a positive additive effect for intramuscular fat content (+1.12% ± 0.21, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f22545ba26f12495ea8162f90cb62d https://doi.org/10.1111/age.13258 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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