Oral supplements of vitamin E improve measures of oxidative stress in plasma and reduce oxidative damage to LDL and erythrocytes in β-thalassemia intermedia patients
| Autor: | Daniele D'Arpa, Maria A. Livrea, Mario Allegra, Luisa Tesoriere, A. Bongiorno, Daniela Butera, Disma Renda, Aurelio Maggio |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Vitamin medicine.medical_specialty Erythrocytes Antioxidant Adolescent medicine.medical_treatment Administration Oral Hematocrit Biochemistry Antioxidants Lipid peroxidation chemistry.chemical_compound Lipid oxidation Reference Values Internal medicine medicine Humans Vitamin E Child Vitamin A medicine.diagnostic_test Osmolar Concentration beta-Thalassemia General Medicine Middle Aged beta Carotene Malondialdehyde Lipids Lipoproteins LDL Oxidative Stress Endocrinology chemistry Case-Control Studies Female Hemoglobin |
| Zdroj: | Free Radical Research. 34:529-540 |
| ISSN: | 1029-2470 1071-5762 |
| DOI: | 10.1080/10715760100300461 |
| Popis: | Fifteen beta-thalassemia intermedia patients, not requiring chronic transfusional therapy, were monitored in order to check their antioxidant status, and the lipid oxidation products in plasma, LDL, and erythrocytes before and during a 9-month oral treatment with 600 mg/day vitamin E. The low level of vitamin E, and high level of malondialdehyde in plasma clearly tended to normalize after three months (P < .001), and were quite similar to control after six months. The abnormally low level of vitamin E in LDL and the four times higher than control basal level of conjugated dienes (LDL-CD), were not modified after three months of treatment. Significant changes of LDL-VE (P < .05) and of the basal LDL-CD (P < .001) were evident after six months. LDL-VE was within the normal range after nine months, whereas LDL-CD still appeared twice as higher than control. Plasma vitamin A, ascorbate, beta-carotene, and lycopene increased markedly at the end of the trial (P < .005). The level of vitamin E in red blood cells was normalized after six months of supplementation. A decrease of the baseline value of conjugated dienes was observed after nine months, although it remained 1.4-fold higher than control. The RBC count and hematocrit appeared higher at the end of the trial (P < .05 and P < .001, respectively). The hemoglobin value did not show variations. A shift to normal of the resistance of erythrocytes to osmotic lysis was observed. Our findings provide evidence that an oral treatment with vitamin E improves the antioxidant/oxidant balance in plasma, LDL particles, and red blood cells, and counteracts lipid peroxidation processes in beta-thalassemia intermedia patients. |
| Databáze: | OpenAIRE |
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