Acute kidney injury following colistin treatment in critically-ill patients: may glucocorticoids protect?
| Autor: | Hayri Ustun Arda, Necati Gokmen, Kübra Canaslan, Serkan Yildiz, Caner Çavdar, Cihan Heybeli, Ali Çelik, Bilgin Comert, Mehmet Asi Oktan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Critical Illness Lower risk Gastroenterology Nephrotoxicity Young Adult Furosemide Risk Factors Intensive care Internal medicine medicine Humans Pharmacology (medical) Prospective cohort study Diuretics Glucocorticoids APACHE Aged Retrospective Studies Pharmacology Aged 80 and over Dose-Response Relationship Drug business.industry Colistin Acute kidney injury Age Factors Odds ratio Acute Kidney Injury Middle Aged medicine.disease Anti-Bacterial Agents Renal Replacement Therapy Infectious Diseases Oncology Socioeconomic Factors Female business Glucocorticoid medicine.drug Glomerular Filtration Rate |
| Zdroj: | Journal of chemotherapy (Florence, Italy). 33(2) |
| ISSN: | 1973-9478 |
| Popis: | Nephrotoxicity following colistin administration is common and factors alleviating nephrotoxicity are yet to be determined. We retrospectively evaluated outcomes of subjects who were treated with colistin (n = 133) and with antibiotics other than colistin (control, n = 133) in intensive care units. Acute kidney injury (AKI) occurred in 69.2% and 29.3% of patients in colistin and control groups, respectively (p < 0.001). In the colistin group, glucocorticoid exposure was more common in subjects who did not develop AKI (p < 0.001). This was not the case in the control group. In the colistin cohort, older age (per 10 years, odds ratio [OR] 1.41, 95% CI 1.05-1.91; p = 0.025), PPI use (OR 3.30, 95% CI 1.18-9.23; p = 0.023) and furosemide treatment (OR 2.66, 95% CI 1.01-6.98; p = 0.047) were independently associated with the development of AKI while glucocorticoid treatment (OR 0.23, 95% CI 0.10-0.53; p = 0.001) was independently associated with reduced risk of AKI. Mortality was observed in 74 patients in the colistin cohort (55.6%). A higher APACHE-II score (OR 1.17, 95% CI 1.08-1.26; p < 0.001) was independently associated with mortality while a higher serum albumin level (per 1 g/dL increase, OR 0.20, 95% CI 0.070-0.60; p = 0.004) was associated with a lower risk of mortality. In conclusion, glucocorticoid exposure is associated with a lower risk of AKI caused by colistin therapy in critically-ill patients. Prospective studies are needed to confirm these findings and determine the optimal type, dose and duration of glucocorticoid therapy. |
| Databáze: | OpenAIRE |
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