The effects of chronic ritanserin treatment on sleep and the neuroendocrine response to L-tryptophan
| Autor: | David J. Nutt, F. J. Mills, Philip J. Cowen, C. Idzikowski |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Radioimmunoassay Ritanserin Binding Competitive Drug withdrawal Piperidines Internal medicine medicine Humans Receptor 5-HT receptor Slow-wave sleep Pharmacology business.industry musculoskeletal neural and ocular physiology Tryptophan Long-term potentiation medicine.disease Receptor antagonist Neurosecretory Systems Prolactin Lysergic Acid Diethylamide Endocrinology nervous system Growth Hormone Sleep Stages business Sleep medicine.drug |
| Popis: | A previous study has shown that acute administration of the 5-HT2 receptor antagonist ritanserin doubles Slow Wave Sleep (SWS) and increases the prolactin (PRL) response to l-tryptophan (LTP). The present study investigated the effect of repeated ritanserin treatment on sleep, neuroendocrine response to LTP and 5-HT2 platelet receptor binding. After 2 weeks, ritanserin administration SWS was persistently increased but the PRL response to LTP was unchanged. Platelet 5-HT receptor binding was undetectable at the end of ritanserin treatment but recovered 2 weeks after drug withdrawal. The results suggest that ritanserin causes a sustained effect on the 5-HT mechanisms mediating SWS and on platelet 5-HT2 receptors. However, adaptation occurs to its effect on 5-HT-mediated neuroendocrine responses. |
| Databáze: | OpenAIRE |
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