Direction and magnitude of nicotine effects on the fMRI BOLD response are related to nicotine effects on behavioral performance

Autor: Juergen Brinkmeyer, Georg Winterer, Francesco Musso, N. Jon Shah, Simone Vossel, Arian Mobascher, Tracy Warbrick, Tony Stoecker
Jazyk: angličtina
Předmět:
Adult
Male
Nicotine
genetic structures
Population
Neuropsychological Tests
Brain mapping
Choice Behavior
behavioral disciplines and activities
Functional Laterality
Superior temporal gyrus
Young Adult
Visual oddball
Double-Blind Method
medicine
Image Processing
Computer-Assisted
Reaction Time
Middle frontal gyrus
Humans
Nicotinic Agonists
education
Oddball paradigm
Anterior cingulate cortex
Administration
Intranasal
Original Investigation
Pharmacology
education.field_of_study
Analysis of Variance
Brain Mapping
Cross-Over Studies
Smoking
Brain
Middle Aged
Magnetic Resonance Imaging
Functional magnetic resonance imaging (fMRI)
Oxygen
medicine.anatomical_structure
Nicotinic agonist
nervous system
Female
Psychology
Neuroscience
Photic Stimulation
psychological phenomena and processes
medicine.drug
Follow-Up Studies
Zdroj: Psychopharmacology
ResearcherID
ISSN: 0033-3158
DOI: 10.1007/s00213-010-2145-8
Popis: Considerable variability across individuals has been reported in both the behavioral and fMRI blood oxygen level-dependent (BOLD) response to nicotine. We aimed to investigate (1) whether there is a heterogeneous effect of nicotine on behavioral and BOLD responses across participants and (2) if heterogeneous BOLD responses are associated with behavioral performance measures. In this double-blind, placebo-controlled, cross-over study, 41 healthy participants (19 smokers)—drawn from a larger population-based sample—performed a visual oddball task after acute challenge with 1 mg nasal nicotine. fMRI data and reaction time were recorded during performance of the task. Across the entire group of subjects, we found increased activation in the anterior cingulate cortex, middle frontal gyrus, superior temporal gyrus, post-central gyrus, planum temporal and frontal pole in the nicotine condition compared with the placebo condition. However, follow-up analyses of this difference in activation between the placebo and nicotine conditions revealed that some participants showed an increase in activation while others showed a decrease in BOLD activation from the placebo to the nicotine condition. A reduction of BOLD activation from placebo to nicotine was associated with a decrease in reaction time and reaction time variability and vice versa, suggesting that it is the direction of BOLD response to nicotine which is related to task performance. We conclude that the BOLD response to nicotine is heterogeneous and that the direction of response to nicotine should be taken into account in future pharmaco-fMRI research on the central action of nicotine. Electronic supplementary material The online version of this article (doi:10.1007/s00213-010-2145-8) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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