Direction and magnitude of nicotine effects on the fMRI BOLD response are related to nicotine effects on behavioral performance
Autor: | Juergen Brinkmeyer, Georg Winterer, Francesco Musso, N. Jon Shah, Simone Vossel, Arian Mobascher, Tracy Warbrick, Tony Stoecker |
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Jazyk: | angličtina |
Předmět: |
Adult
Male Nicotine genetic structures Population Neuropsychological Tests Brain mapping Choice Behavior behavioral disciplines and activities Functional Laterality Superior temporal gyrus Young Adult Visual oddball Double-Blind Method medicine Image Processing Computer-Assisted Reaction Time Middle frontal gyrus Humans Nicotinic Agonists education Oddball paradigm Anterior cingulate cortex Administration Intranasal Original Investigation Pharmacology education.field_of_study Analysis of Variance Brain Mapping Cross-Over Studies Smoking Brain Middle Aged Magnetic Resonance Imaging Functional magnetic resonance imaging (fMRI) Oxygen medicine.anatomical_structure Nicotinic agonist nervous system Female Psychology Neuroscience Photic Stimulation psychological phenomena and processes medicine.drug Follow-Up Studies |
Zdroj: | Psychopharmacology ResearcherID |
ISSN: | 0033-3158 |
DOI: | 10.1007/s00213-010-2145-8 |
Popis: | Considerable variability across individuals has been reported in both the behavioral and fMRI blood oxygen level-dependent (BOLD) response to nicotine. We aimed to investigate (1) whether there is a heterogeneous effect of nicotine on behavioral and BOLD responses across participants and (2) if heterogeneous BOLD responses are associated with behavioral performance measures. In this double-blind, placebo-controlled, cross-over study, 41 healthy participants (19 smokers)—drawn from a larger population-based sample—performed a visual oddball task after acute challenge with 1 mg nasal nicotine. fMRI data and reaction time were recorded during performance of the task. Across the entire group of subjects, we found increased activation in the anterior cingulate cortex, middle frontal gyrus, superior temporal gyrus, post-central gyrus, planum temporal and frontal pole in the nicotine condition compared with the placebo condition. However, follow-up analyses of this difference in activation between the placebo and nicotine conditions revealed that some participants showed an increase in activation while others showed a decrease in BOLD activation from the placebo to the nicotine condition. A reduction of BOLD activation from placebo to nicotine was associated with a decrease in reaction time and reaction time variability and vice versa, suggesting that it is the direction of BOLD response to nicotine which is related to task performance. We conclude that the BOLD response to nicotine is heterogeneous and that the direction of response to nicotine should be taken into account in future pharmaco-fMRI research on the central action of nicotine. Electronic supplementary material The online version of this article (doi:10.1007/s00213-010-2145-8) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
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