Mechanisms Inducing or Controlling CD8+T Cell Responses against Self- or Non-Self-Antigens
| Autor: | Daniele Accapezzato, Vittorio Francavilla, Marino Paroli, Antonella Propato, Vincenzo Barnaba |
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| Rok vydání: | 2003 |
| Předmět: |
General Neuroscience
T cell Antigen presentation CD1 Cross-presentation CD8-Positive T-Lymphocytes Biology Major histocompatibility complex General Biochemistry Genetics and Molecular Biology Cell biology medicine.anatomical_structure History and Philosophy of Science MHC class I Immunology biology.protein medicine Humans Cytotoxic T cell Antigens Antigen-presenting cell |
| Zdroj: | Sapienza Università di Roma-IRIS |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.2003.tb06037.x |
| Popis: | Cytotoxic T lymphocytes (CTLs) generally recognize antigens en-dogenously synthesized within the cells and presented in the form of peptides on class I molecules. However, a large body of evidence suggests that dendritic cells (DCs) have the capacity to capture and deliver exogenous antigens into the major histocompatibility complex (MHC) class I processing pathway. In this paper, we discuss this function, defined as cross-presentation, and how it is directed, particularly in inducing T cell tolerance, and how it requires special activating signals (such as CD40 ligand) to transform into a mechanism that provides either protective immunity or autoimmunity. |
| Databáze: | OpenAIRE |
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