Immunopathogenesis Versus Protection in Dengue Virus Infections
| Autor: | Jeffrey R. Currier, Carey L. Medin, Heather Friberg, Alan L. Rothman |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Serotype
Innate immune system viruses virus diseases Context (language use) Biology Dengue virus biochemical phenomena metabolism and nutrition medicine.disease medicine.disease_cause Virology Article Dengue fever Infectious Diseases Immune system Parasitology Immunology medicine Immunology and Allergy Viral disease |
| Popis: | Dengue viruses (DENV) are mosquito-borne viruses that cause significant morbidity. The existence of four serotypes of DENV with partial immunologic cross-reactivity creates the opportunity for individuals to experience multiple acute DENV infections over the course of their lifetimes. Research over the past several years has revealed complex interactions between DENV and the human innate and adaptive immune systems that can have either beneficial or detrimental influences on the outcome of infection. Further studies that seek to distinguish protective from pathological immune responses in the context of natural DENV infection, as well as clinical trials of candidate DENV vaccines, are an important part of efforts to control the global impact of this re-emerging viral disease. |
| Databáze: | OpenAIRE |
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