Functional estrogen receptor signal transduction pathway activity and antihormonal therapy response in low-grade ovarian carcinoma
| Autor: | Cynthia S. E. Hendrikse, Phyllis van der Ploeg, Nienke M. A. van de Kruis, Jody H. C. Wilting, Floor Oosterkamp, Pauline M. M. Theelen, Christianne A. R. Lok, Joanne A. de Hullu, Huberdina P. M. Smedts, M. Caroline Vos, Brenda M. Pijlman, Loes F. S. Kooreman, Johan Bulten, Marjolein H. F. M. Lentjes‐Beer, Steven L. Bosch, Anja van de Stolpe, Sandrina Lambrechts, Ruud L. M. Bekkers, Jurgen M. J. Piek |
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| Přispěvatelé: | Obstetrie & Gynaecologie, RS: GROW - R2 - Basic and Translational Cancer Biology, Pathologie, MUMC+: DA Pat Pathologie (9), MUMC+: MA Medische Staf Obstetrie Gynaecologie (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
antihormonal therapy
ovarian carcinoma EXPRESSION Cancer Research All institutes and research themes of the Radboud University Medical Center CANCER STATISTICS Oncology immunohistochemistry signal transduction pathway WOMEN targeted therapy survival Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] |
| Zdroj: | Cancer, 129(9), 1361-1371. Wiley Cancer, 129, 9, pp. 1361-1371 Cancer, 129, 1361-1371 |
| ISSN: | 0008-543X |
| Popis: | Contains fulltext : 291887.pdf (Publisher’s version ) (Open Access) BACKGROUND: Advanced low-grade ovarian carcinoma (LGOC) is difficult to treat. In several studies, high estrogen receptor (ER) protein expression was observed in patients with LGOC, which suggests that antihormonal therapy (AHT) is a treatment option. However, only a subgroup of patients respond to AHT, and this response cannot be adequately predicted by currently used immunohistochemistry (IHC). A possible explanation is that IHC only takes the ligand, but not the activity, of the whole signal transduction pathway (STP) into account. Therefore, in this study, the authors assessed whether functional STP activity can be an alternative tool to predict response to AHT in LGOC. METHODS: Tumor tissue samples were obtained from patients with primary or recurrent LGOC who subsequently received AHT. Histoscores of ER and progesterone receptor (PR) were determined. In addition, STP activity of the ER STP and of six other STPs known to play a role in ovarian cancer was assessed and compared with the STP activity of healthy postmenopausal fallopian tube epithelium. RESULTS: Patients who had normal ER STP activity had a progression-free survival (PFS) of 16.1 months. This was significantly shorter in patients who had low and very high ER STP activity, with a median PFS of 6.0 and 2.1 months, respectively (p |
| Databáze: | OpenAIRE |
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