Invasive Fungal Infection in Romania: Changing Incidence and Epidemiology During Six Years of Surveillance in a Tertiary Hospital
| Autor: | Floredana-Laura Şular, Violeta Corina Cristea, Minodora Dobreanu, Edit Szekely |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Antifungal Veterinary medicine medicine.medical_specialty Antifungal Agents Adolescent Echinocandin medicine.drug_class Veterinary (miscellaneous) 030106 microbiology Microbial Sensitivity Tests Biology Applied Microbiology and Biotechnology Microbiology Hospitals University Tertiary Care Centers Young Adult 03 medical and health sciences Medical microbiology Drug Resistance Fungal Epidemiology medicine Humans Child Aged Candida Aged 80 and over Romania Incidence Incidence (epidemiology) Infant Newborn Candidemia Infant Middle Aged Corpus albicans Eastern european Child Preschool Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Epidemiological Monitoring Female Agronomy and Crop Science Fluconazole medicine.drug |
| Zdroj: | Mycopathologia. 183:967-972 |
| ISSN: | 1573-0832 0301-486X |
| DOI: | 10.1007/s11046-018-0293-2 |
| Popis: | The present study aimed to evaluate the incidence of candidemia, the trend of species distribution and the antifungal susceptibility patterns of all invasive strains of Candida spp. isolated over a 6-year period in an Eastern European University hospital. A total number of 156 isolates were reidentified by MALDI-TOF and tested for susceptibility by SensititreTM YeastOne™. Isolates were assigned as non-susceptible or belonging to the wild type according to the new CLSI (2017, 2018) break points and epidemiological cut-off values. C. parapsilosis (37.82%) was the most frequently isolated yeast, followed by C. albicans (26.28%). The general tendency of the species distribution during the surveyed period shifted towards an increase in C. parapsilosis and C. lusitaniae isolates. Fluconazole resistance was present in 23.52% of C. glabrata, 5.08% of C. parapsilosis and in none of the C. albicans, C. tropicalis and C. lusitaniae isolates. Echinocandin resistance was present only in 1(5.88%) C. glabrata isolate. The study emphasises the importance of monitoring local epidemiologic data and antifungal susceptibility trends due to the diversity of affected patient groups in our hospital. |
| Databáze: | OpenAIRE |
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