Ultrasensitive Phototriggered Local Anesthesia
| Autor: | Brian P. Timko, Changyou Zhan, Alina Y. Rwei, Bruce Wang, Weiping Wang, Daniel S. Kohane, Claudia M. Santamaria |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Light medicine.drug_class Infrared Rays Surface Properties medicine.medical_treatment Bioengineering Nanotechnology 02 engineering and technology Tetrodotoxin 010402 general chemistry 01 natural sciences Article medicine Animals General Materials Science Local anesthesia Tissue Distribution Irradiation Particle Size Nanotubes Local anesthetic Mechanical Engineering Nerve Block General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics Sciatic Nerve 0104 chemical sciences Intensity (physics) Rats Drug Liberation Liposomes Nerve block Continuous wave Nanorod Sciatic nerve Gold 0210 nano-technology Dexmedetomidine Biomedical engineering Anesthesia Local |
| Popis: | An injectable local anesthetic producing repeatable on-demand nerve block would be desirable for pain management. Here we present a phototriggerable device to achieve repeatable and adjustable on-demand local anesthesia in superficial or deep tissues, consisting of gold nanorods attached to low temperature sensitive liposomes (LTSL). The particles were loaded with tetrodotoxin and dexmedetomidine. Near-infrared light (NIR, 808 nm, continuous wave) could heat gold nanorods at low fluence (short duration and low irradiance), leading to rapid release of payload. In vivo, 1–2 min of irradiation at ≤272 mW/cm2 produced repeatable and adjustable on-demand infiltration anesthesia or sciatic nerve blockade with minimal toxicity. The nerve block intensity and duration correlated with the irradiance and duration of the applied light. |
| Databáze: | OpenAIRE |
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