CXCL12 G801A polymorphism is associated with significant liver fibrosis in HIV-infected Thais: a cross-sectional study
| Autor: | Warisara Sretapunya, Thitiilat Chiraunyanann, Chareeporn Akekawatchai, Khaimuk Changsri, Kornanong Yuenyongchaiwat |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Liver Cirrhosis Male 0301 basic medicine medicine.medical_specialty Genotype Immunology HIV Infections Single-nucleotide polymorphism Thais Polymorphism Single Nucleotide Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Immunology and Allergy SNP Alleles biology business.industry Sequence Analysis DNA General Medicine Middle Aged Hepatitis B Thailand medicine.disease biology.organism_classification Chemokine CXCL12 Cross-Sectional Studies 030104 developmental biology 030220 oncology & carcinogenesis Transaminitis Coinfection Female business Hepatic fibrosis Biomarkers |
| Zdroj: | Asian Pacific Journal of Allergy and Immunology. |
| ISSN: | 0125-877X |
| DOI: | 10.12932/ap-160917-0162 |
| Popis: | BACKGROUND Previous studies indicate high prevalence of liver diseases in HIV-infected patients, and their genetic risk factors are still unclear. The chemokine CXCL12 plays important roles in development of chronic liver injury and a single nucleotide polymorphism (SNP) G to A change at position 801 in CXCL12 gene has been demonstrated to affect CXCL12 production levels. OBJECTIVE This study aimed to analyze the association of CXCL12 G801A SNP with liver complication in HIV-infected Thais. METHODS A cross-sectional study was conducted in 164 patients who were evaluated for transaminitis and significant liver fibrosis, defined by fibrosis-4 (FIB-4) score and AST to platelet ratio index (APRI), and genotyped for the SNP using tetra-primer PCR-SSP. RESULTS There were high rates of patients with transaminits (28.0%), and significant liver fibrosis by FIB-4 score (18.9%) and by APRI (14.0%). The CXCL12 G801A AA/GA genotypes were significantly associated with transaminitis (p = 0.014) and significant fibrosis by APRI (p = 0.020). Univariate and multivariate analyses identified the AA/GA genotypes as predictive factors for significant fibrosis (OR 6.8, 95%CI 1.7-28.2, p = 0.008), together with age older than 40 years, CD4+ cell count < 350 cells/μl and hepatitis B and/or C virus coinfection. The significantly higher medians of APRI and FIB-4 score, in patients with AA/GA than those with GG genotypes (p < 0.05) were observed in the ART-naive, but not ART-experienced groups. CONCLUSION The CXCL12 G801A AA/GA genotypes are significant predictive factors for hepatic fibrosis potentially in the ART-naive HIV-infected Thais. |
| Databáze: | OpenAIRE |
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