Immunohistochemical Study of PD-1/PD-L1 Axis Expression in Oral Tongue Squamous Cell Carcinomas: Effect of Neoadjuvant Chemotherapy on Local Recurrence
| Autor: | Hiroki Tsuchihashi, Keisuke Ohmori, Kohei Okuyama, Masahiro Umeda, Souichi Yanamoto, Kohei Furukawa, Shin-ichi Yamada, Tomofumi Naruse |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Male Cancer Research medicine.medical_specialty medicine.medical_treatment Programmed Cell Death 1 Receptor B7-H1 Antigen Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Immune system Lymphocytes Tumor-Infiltrating Tongue PD-L1 Internal medicine medicine Tumor Microenvironment Humans Radical surgery Aged Retrospective Studies Tumor microenvironment Chemotherapy biology business.industry Squamous Cell Carcinoma of Head and Neck General Medicine Middle Aged Immunohistochemistry Neoadjuvant Therapy Tongue Neoplasms 030104 developmental biology medicine.anatomical_structure Disease-specific Survival Rate Chemotherapy Adjuvant 030220 oncology & carcinogenesis biology.protein Female Neoplasm Recurrence Local business |
| Zdroj: | Pathology oncology research : POR. 26(2) |
| ISSN: | 1532-2807 |
| Popis: | While neoadjuvant chemotherapy (NAC) for patients with oral tongue squamous cell carcinoma (OTSCC) may improve tumor microenvironment, it may lead to local immune suppression caused by residual cancer cells. The efficacy of NAC is therefore controversial. In our study, we investigated tumor microenvironments after NAC using immune checkpoint molecules, and evaluated the association between tumor microenvironments, clinicopathological factors and outcomes. We reviewed the records of 121 patients who underwent radical surgery for OTSCC between April 2001 and March 2015. Patients with a positive surgical margin and a follow up period of less than 6 months were excluded. For these patients, programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) expressions were immunohistochemically examined. The expression of PD-1 and PD-L1 were significantly associated with local recurrence in patients with OTSCC (P |
| Databáze: | OpenAIRE |
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