Excretory, Secretory, and Tissue Residues after Label and Extra-label Administration of Flunixin Meglumine to Saline- or Lipopolysaccharide-Exposed Dairy Cows
| Autor: | J. W. Schroeder, David J. Smith, Jim E. Riviere, Grant R. Herges, Ronette Gehring, Terry J. Dutko, Mengjie Li, Weilin L. Shelver, Lisa A. Tell, Ronald E. Baynes |
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| Rok vydání: | 2015 |
| Předmět: |
Lipopolysaccharides
Flunixin Lipopolysaccharide medicine.medical_treatment Urinary system Urine Sodium Chloride Kidney chemistry.chemical_compound Animal science Medicine Animals Muscle Skeletal Saline Dairy cattle Drug Labeling Inflammation business.industry Anti-Inflammatory Agents Non-Steroidal food and beverages Veterinary Drugs General Chemistry Metabolism Drug Residues Clonixin Milk chemistry Adipose Tissue Liver Cattle Female General Agricultural and Biological Sciences business Intramuscular injection medicine.drug |
| Zdroj: | Journal of agricultural and food chemistry. 63(19) |
| ISSN: | 1520-5118 |
| Popis: | Twenty lactating dairy cattle were intravenously infused with either lipopolysaccharide (LPS) (n = 10) or sterile saline (n = 10). Five cattle in each group received three doses of flunixin meglumine administered by either intravenous infusion or intramuscular injection at 24 h intervals. Milk, urine, and tissues were collected. Thirty-six hours after the last flunixin administration, milk from six cows contained 5-hydroxyflunixin (5OHF) levels greater than the milk tolerance of 2 ng/mL; by 48 h, milk from two cows, a saline and a LPS-treated animal, had violative milk concentrations of 5OHF. A single animal treated with LPS and intramuscular flunixin contained violative flunixin residues in liver. The ratio of urinary flunixin/5OHF was correlated (P0.01; R(2) = 0.946) with liver flunixin residues in LPS-treated animals, but not (P = 0.96; R(2) = 0.003) in cows treated with saline in lieu of LPS. Violative residues of flunixin in dairy cattle may be related to LPS inhibition of flunixin metabolism. |
| Databáze: | OpenAIRE |
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