Common and distinct neural connectivity in attention‐deficit/hyperactivity disorder and alcohol use disorder studied using resting‐state functional magnetic resonance imaging
| Autor: | Sabine Vollstädt-Klein, Àlvar Farré-Colomés, Mathias Luderer, Falk Kiefer, Sarah Gerhardt, Esther Sobanski |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Prefrontal Cortex 030508 substance abuse Medicine (miscellaneous) Alcohol use disorder Toxicology Young Adult 03 medical and health sciences 0302 clinical medicine Neuroimaging Task-positive network Neural Pathways mental disorders Brodmann area 6 medicine Humans Attention deficit hyperactivity disorder Prefrontal cortex Default mode network Functional Neuroimaging Motor Cortex Brain Default Mode Network Middle Aged medicine.disease Magnetic Resonance Imaging Comorbidity Alcoholism Psychiatry and Mental health Attention Deficit Disorder with Hyperactivity Case-Control Studies Female 0305 other medical science Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 45:948-960 |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/acer.14593 |
| Popis: | BACKGROUND: The relation between Attention Deficit/Hyperactivity Disorder (ADHD) and Alcohol Use Disorder (AUD) has been widely demonstrated. In this study, we aimed to investigate the connectivity traits that would help to understand the strong link between both disorders using a neuroimaging perspective. METHODS: The study included an AUD group (N = 18), an ADHD group (N = 17), a group with AUD+ADHD comorbidity individuals (N = 12) and a control group (N = 18). We used resting-state functional connectivity in a seed-based approach in the Default Mode Networks, the Dorsal Attention Network and the Salience Network. RESULTS: Within the Default Mode Networks, all groups shared increased connectivity towards the Temporal Gyrus when compared to the control group. Regarding the Dorsal Attention Network, the Brodmann Area 6 presented increased connectivity for each disorder group in comparison with the control group, displaying the strongest aberrations in the AUD+ADHD group. In the Salience Network, the Prefrontal Cortex showed decreased connectivity in every disorder group compared to the control group. CONCLUSIONS: Despite the small and unequal sample size, our study suggests common neurobiological alterations in AUD and ADHD, supporting the hypothesis that ADHD might be a risk factor for the development of an AUD. The results highlight the importance of an early ADHD diagnosis and treatment to reduce this risk for a subsequent AUD. |
| Databáze: | OpenAIRE |
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