The mammalian Crx genes are highly divergent representatives of the Otx5 gene family, a gnathostome orthology class of orthodenticle-related homeogenes involved in the differentiation of retinal photoreceptors and circadian entrainment

Autor: Agnès Germot, Tatjana Sauka-Spengler, Gavan Harrison, Jean-Louis Plouhinec, Sylvie Mazan, Chantal Le Mentec, Thérèse Cabana, Jean-Yves Sire, Géraldine Véron, Claude Pieau
Přispěvatelé: Unité de Génétique Moléculaire Animale (UGMA), Université de Limoges (UNILIM)-Institut National de la Recherche Agronomique (INRA), Unité de Génétique Moléculaire Animale (UMR GMA), Institut National de la Recherche Agronomique (INRA)-Université de Limoges (UNILIM), Immunologie et Embryologie Moléculaires (IEM), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), ProdInra, Archive Ouverte
Jazyk: angličtina
Rok vydání: 2003
Předmět:
[SDV]Life Sciences [q-bio]
Molecular Sequence Data
Cladistia
Evolution
Molecular
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Chordata
Nonvertebrate
Gene Duplication
Gene duplication
Genetics
Animals
Gene family
Coding region
Photoreceptor Cells
Amino Acid Sequence
[SDV.BDD]Life Sciences [q-bio]/Development Biology
Molecular Biology
Gene
Phylogeny
Ecology
Evolution
Behavior and Systematics
030304 developmental biology
Homeodomain Proteins
0303 health sciences
Otx Transcription Factors
Sequence Homology
Amino Acid
biology
Phylogenetic tree
Fishes
Genetic Variation
Cell Differentiation
Retinal
Zebrafish Proteins
biology.organism_classification
Circadian Rhythm
[SDV] Life Sciences [q-bio]
Gastrulation
chemistry
Dogfish
Trans-Activators
sense organs
030217 neurology & neurosurgery
Zdroj: Molecular Biology and Evolution
Molecular Biology and Evolution, Oxford University Press (OUP), 2003, 20, pp.513-521
ISSN: 0737-4038
1537-1719
Popis: The mammalian Crx genes are highly divergent orthodenticle (otd)-related homeogenes that play important roles in the differentiation of retinal photoreceptors and the circadian entrainment. However, their evolutionary origin and orthological relationships with other otd-related genes remain unclear. An orthology relationship of these genes with the highly conserved Otx5 genes identified in fish and amphibians, and also expressed in the eye and epiphysis, has been proposed previously but remains controversial. To test this hypothesis, we have identified Crx genes in a wide range of mammals, including three marsupials, and Otx5-related genes in a lizard, a turtle, and two archosaurs (crocodile and chick), as well as in the pufferfish. Phylogenetic analyses of the coding sequences show that the mammalian Crx genes are orthologous to the Otx5-related genes isolated in other gnathostomes. They also indicate that a duplication event has taken place in actinopterygians, after the splitting of the Cladistia, and that a relaxation of the structural constraints acting on the gene coding region has occurred early in the mammalian lineage. This process may be linked not only to the loss of ancestral Otx5/Crx functions during gastrulation or in the retinal pigmented epithelium, but also to the evolution of photic entrainment mechanisms in mammals.
Databáze: OpenAIRE
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