Population Pharmacokinetics of Piperaquine in Young Ugandan Children Treated With Dihydroartemisinin-Piperaquine for Uncomplicated Malaria
| Autor: | Jordan W. Tappero, Joel Tarning, Shelley A. McCormack, Li Yan, Nancy C. Sambol, François Nosten, Francesca T. Aweeka, Darren J. Creek, Emmanuel Arinaitwe, Sunil Parikh, Victor Bigira, Niklas Lindegardh, Abel Kakuru, Humphrey Wanzira |
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| Rok vydání: | 2015 |
| Předmět: |
Pediatrics
medicine.medical_specialty medicine.medical_treatment Dihydroartemisinin Article Antimalarials Pharmacotherapy Pharmacokinetics Dihydroartemisinin/piperaquine Piperaquine medicine Humans Uganda Pharmacology (medical) Prospective Studies Dosing Prospective cohort study Pharmacology business.industry Infant medicine.disease Artemisinins Malaria Child Preschool Quinolines Drug Therapy Combination business |
| Zdroj: | Clinical Pharmacology & Therapeutics. 98:87-95 |
| ISSN: | 0009-9236 |
| DOI: | 10.1002/cpt.104 |
| Popis: | This prospective trial investigated the population pharmacokinetics of piperaquine, given with dihydroartemisinin to treat uncomplicated malaria in 107 Ugandan children 6 months to 2 years old, an age group previously unstudied. Current weight-based dosing does not adequately address physiological changes in early childhood. Patients were administered standard three-day oral doses and provided 1,282 capillary plasma concentrations from 218 malaria episodes. Less than 30% of treatments achieved 57 ng/mL on day 7. A three-compartment model with first-order absorption described the data well. Age had a statistically significant effect (p |
| Databáze: | OpenAIRE |
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