Genetic Diversity of Hantaviruses Isolated in China and Characterization of Novel Hantaviruses Isolated from Niviventer confucianus and Rattus rattus
| Autor: | Hideki Ebihara, Hua Wang, Dexin Li, Jiro Arikawa, Zhaoxiao Wang, Hiroaki Kariwa, Zhaozhuang Luo, Michiko Ogino, Changshou Hang, Kumiko Yoshimatsu, Koichi Araki |
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| Rok vydání: | 2000 |
| Předmět: |
China
Orthohantavirus Hantavirus Infections viruses Rodentia Biology Amur virus Virus Rodent Diseases Niviventer confucianus Cricetulus Japan Cricetinae Virology Genetic variation Animals Humans cardiovascular diseases education Phylogeny Hantaan virus Genetics Genetic diversity education.field_of_study Korea Geography Phylogenetic tree Reverse Transcriptase Polymerase Chain Reaction Genetic Variation virus diseases biology.organism_classification Rats Europe Muridae North America Seoul virus |
| Zdroj: | Virology. 278:332-345 |
| ISSN: | 0042-6822 |
| Popis: | The antigenic and genetic properties of 46 hantaviruses from China, 13 from patients, 23 from rodents, and 10 from unknown hosts, were compared with those of other hantaviruses. The viruses were classified as either Hantaan (HTN) or Seoul (SEO) viruses. A phylogenetic analysis of the partial M (300 bp) and S (around 485 bp) genomes of HTN viruses identified nine distinct genetic subtypes, one consisting of isolates from Korea. The SEO viruses were divided into five genetic subtypes, although they had less variability than the HTN subtypes. There was a correlation between the subtype and province of origin for four subtypes of HTN viruses, confirming geographical clustering. Hantaan virus NC167 isolated from Niviventer confucianus and SEO virus Gou3 isolated from Rattus rattus were the basal clades in each virus. The phylogenetic trees constructed from the entire S and M segments suggested that NC167 was introduced to N. confucianus in a host-switching event. The reactivity of a panel of 35 monoclonal antibodies was almost exactly the same in NC167 and a representative HTN virus and in Gou3 and a representative SEO virus. However, there was a one-way cross-neutralization between them. These results confirm the varied nature of Murinae-associated hantaviruses in China. |
| Databáze: | OpenAIRE |
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