Effect of co-infection with intestinal parasites on COVID-19 severity: A prospective observational cohort study
| Autor: | Zekarias Gessesse Arefaine, Vanessa C. Harris, Frehiwot Kassahun Miteku, Mahmud Abdulkader, Ebba Abate, Atsbeha Gebreegzabher, Kidist Lakew Endarge, Masresha Tesema, Getachew Tollera, Tsegaye Gebreyes Hundie, Ataklti Hailu, Teklay Gebrecherkos, Henk H.D.F. Schallig, Britta C. Urban, Tobias F. Rinke de Wit, Yazezew Kebede Kiros, Dawit Wolday, Hiluf Ebuy Abraha, Geremew Tasew, Saro Abdella, Abraham Aregay Desta |
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| Přispěvatelé: | AII - Amsterdam institute for Infection and Immunity, APH - Global Health, APH - Health Behaviors & Chronic Diseases, Global Health, Infectious diseases, AII - Infectious diseases, APH - Personalized Medicine, APH - Quality of Care |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Medicine (General) Coronavirus disease 2019 (COVID-19) Logistic regression Severity Immune system co-infection R5-920 Informed consent Internal medicine wc_505 medicine media_common.cataloged_instance Parasite hosting Helminths European union media_common wa_105 business.industry Public health COVID-19 General Medicine Odds ratio wc_698 wc_695 Clinical trial africa parasite business Body mass index Research Paper Co infection Cohort study Biomedical sciences |
| Zdroj: | EClinicalMedicine, Vol 39, Iss, Pp 101054-(2021) EClinicalMedicine, 39:101054. Lancet Publishing Group EClinicalMedicine |
| ISSN: | 2589-5370 |
| Popis: | Background: COVID-19 symptomatology in Africa appears significantly less serious than in the industrialized world. We and others previously postulated a partial explanation for this phenomenon, being a different, more activated immune system due to parasite infections. We investigated this hypothesis in an endemic area in Africa. Methods: Ethiopian COVID-19 patients were enrolled and screened for intestinal parasites. The primary outcome was the proportion of patients with severe COVID-19. Logistic regression models were used to estimate the association between parasite infection, and COVID-19 severity. Models were adjusted for sex, age, residence, and comorbidities. Findings: 751 SARS-CoV-2 infected patients were enrolled, of whom 284 (37·8%) had intestinal parasitic infection. Only 27/255 (10·6%) severe COVID-19 patients were co-infected with intestinal parasites, while 257/496 (51·8%) non-severe COVID-19 patients appeared parasite positive (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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