Prompt Differentiation of Addisonʼs Disease From Anorexia Nervosa During Weight Loss and Vomiting

Autor: Lippmann S, El Asyouty S, McQuillen M, Sutherland S, Hinkebein Mk, Roger Adams
Rok vydání: 1998
Předmět:
Zdroj: Southern Medical Journal. 91:208-211
ISSN: 0038-4348
DOI: 10.1097/00007611-199802000-00017
Popis: An 18-year-old white woman had nausea, vomiting, weight loss, and a diagnosis of anorexia nervosa. Copper-colored skin was noted on physical examination, and serum chemistry values were normal. Subsequent fever, disorientation, and confusion led to the discovery of Addison's disease, which responded well to corticosteroid replacement therapy. Addisonian and anorexic patients exhibit clinical similarities, including nausea, vomiting, weight loss, abdominal pain, cold intolerance, hypothermia, and orthostasis. Other commonalities include prolongation of electrocardiographic PR and QT intervals and generalized slowing on electroencephalogram. Important differences include a brown color to the skin in Addison's disease instead of a yellowish color in anorexia. Addisonian patients also display hypocortisolism, hypoglycemia, and hyperkalemia, in contrast to the hypercortisolism, hyperglycemia, and hypokalemia seen in anorexia.
Databáze: OpenAIRE
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