The relationship of daytime hypoxemia and nocturnal hypoxia in obstructive sleep apnea syndrome
| Autor: | Rossella Trentin, Nadia D'Artavilla Lupo, Mario Grassi, Francesco Fanfulla, Anna Eugenia Taurino |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Polysomnography Severity of Illness Index Hypoxemia Physiology (medical) medicine Prevalence Humans Lung volumes Respiratory function Hypoxemia and Sleep Apnea Hypoxia COPD Sleep Apnea Obstructive medicine.diagnostic_test business.industry Sleep apnea Airway obstruction Middle Aged medicine.disease respiratory tract diseases Circadian Rhythm Obstructive sleep apnea Anesthesia Female Neurology (clinical) medicine.symptom Blood Gas Analysis business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0161-8105 |
| Popis: | SLEEP APNEA IS A CHRONIC CONDITION CHARACTERIZED BY UPPER AIRWAY COLLAPSE DURING SLEEP. THE RESULTING DECREASE OR CESSATION OF airflow is generally associated with recurrent drops in oxyhemoglobin saturation. Gas exchange during sleep may be severely affected in certain patients, especially in those who are grossly obese or have chronic respiratory disorders, such as chronic obstructive pulmonary disease (COPD).1–2 Daytime hypoxemia has been reported to develop in patients with obstructive sleep apnea (OSA).3–8 In the past, looking for the physiological determinants of nocturnal arterial oxygenation in OSA patients, it was found that derangements of pulmonary mechanics and awake PaO2 were of major importance in establishing the severity of nocturnal hypoxemia.9 Other studies showed that the main determinant of daytime hypoxemia is not the OSA per se but rather concomitant comorbidity such as COPD.7–8,10 However, all these studies were performed on heterogeneous populations with a very high prevalence of COPD patients, so that airway obstruction and lung hyperinflation had major roles in determining the lower values of PaO2. Moreover, the PaO2 level at rest is highly dependent on age, and none of the studies previously cited corrected the level of PaO2 for age, thus invalidating any comparisons of the level of oxygenation in patients with widely different ages. The aims of the current study were: (i) to estimate the prevalence of alterations in daytime oxygenation in a very large group of OSA patients with a very broad spectrum of disease severity and obesity; (ii) to assess the reciprocal (feedback) effects between daytime PaO2 and nocturnal SaO2, adjusted for comorbidities such as obesity and lung volumes; and (iii) to investigate the direct and indirect role of sleep apnea severity in determining feedback gas exchange abnormalities. Some of the results of this study have been previously reported in the form of an abstract.11 |
| Databáze: | OpenAIRE |
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