Health status, health-related quality of life, and socioeconomic outcome in childhood brain tumor survivors: a German cohort study
| Autor: | Andreas Hinz, Katja Baust, Dagmar Dilloo, Astrid Gnekow, Kiana Kreitz, Ursula Creutzig, Stefan Rutkowski, Thorsten Langer, Gabriele Calaminus, Carmen Teske, Susanne Singer, Leonie Weinhold, Peter Kaatsch, Matthias Schmid, Claudia Spix, Cathy Scholtes |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
State of health Health Status Population Cohort Studies 03 medical and health sciences 0302 clinical medicine Quality of life Surveys and Questionnaires Humans Medicine Survivors Child education Socioeconomic status education.field_of_study Brain Neoplasms business.industry Confounding Editorials Cancer medicine.disease humanities Socioeconomic Factors Oncology 030220 oncology & carcinogenesis Cohort Quality of Life Neurology (clinical) business Pediatric Neuro-Oncology 030217 neurology & neurosurgery Cohort study Demography |
| Zdroj: | Neuro Oncol |
| Popis: | Background With rising numbers of childhood cancer survivors, somatic and socioeconomic outcome as well as health-related quality of life (QoL) gain increasing relevance. Based on the first nationwide German Survey on Life Situation, State of Health, and Quality of Life of Childhood Cancer Survivors, the VIVE survey, we report the outcome of survivors of childhood brain tumors localized in the posterior fossa. Methods Two hundred seventy participants with a median follow-up period of 21.9 years completed a questionnaire on socioeconomic and somatic late effects as well as a standardized QoL questionnaire (European Organisation for Research and Treatment of Cancer QLQ-C30). Comparisons were performed between World Health Organization (WHO) grades I–II, WHO grades III–IV brain tumor survivors (BTS), and the general population adjusting for potential confounders. Results The socioeconomic and QoL results of WHO grades I–II BTS were largely comparable to the general population, while grades III–IV BTS were at higher risk for significantly worse outcomes. Of WHO grades III–IV BTS, 36.8% were still living with their parents or in assisted living facilities compared with 16.1% of grades I–II BTS and 7.8% of the age-adjusted general population. Of grades III–IV BTS, 60.8% achieved at least an intermediate school degree in comparison to 80.5% of grades I–II BTS and 75.6% of the general population. Grades III–IV BTS developed up to 2 times more somatic late effects than survivors of grades I–II tumors. Conclusion Derived from a large and homogeneous cohort, these results stress the importance of an appropriate follow-up period focusing not only on physical aspects but encompassing the entire living situation to allow patient-tailored support. |
| Databáze: | OpenAIRE |
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