Identification of Western Equine Encephalitis Virus Structural Proteins That Confer Protection after DNA Vaccination▿

Autor:	Penelope J. Gauci, Nicole D. Barabé, Josh Q.H. Wu, Leslie P. Nagata, George A. Rayner, David Proll
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	Microbiology (medical) Encephalomyelitis Equine Clinical Biochemistry Immunology Heterologous Biology medicine.disease_cause Recombinant virus Virus Encephalitis Virus Western Equine DNA vaccination Mice Immune system medicine Vaccines DNA Immunology and Allergy Animals Antigens Viral Viral Structural Proteins Mice Inbred BALB C Western equine encephalitis virus Viral Vaccine Viral Vaccines Vaccine Research Virology Survival Analysis Vaccination Disease Models Animal Female
Popis:	DNA vaccines encoding different portions of the structural proteins of western equine encephalitis virus were tested for the efficacy of their protection in a 100% lethal mouse model of the virus. The 6K-E1 structural protein encoded by the DNA vaccine conferred complete protection against challenge with the homologous strain and limited protection against challenge with a heterologous strain.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d3651ef6ed948b8a7b9b77521d2770 https://europepmc.org/articles/PMC2812089/ Zobrazit plný text záznamu