High sustained virologic response rates in children with chronic hepatitis C receiving peginterferon alfa-2b plus ribavirin
| Autor: | Henry Pollack, Thomas Lang, Norberto Rodriguez-Baez, Teresita Gonzalez, Janice K. Albrecht, Clifford A. Brass, Estella M. Alonso, Alain Lachaux, Stephanie Noviello, Marcela Galoppo, Wolf Deitrich Huber, F. Lacaille, Maria Angeles Calzado, Vilma Sniukiene, Nanda Kerkar, Jyoti Ramakrishna, Stefan Wirth, Antonio Del Valle-Segarra, Alejandra Pedreira, Mirta Ciocca, Flavia Bortolotti, Christine Xu, M Shelton, Carmen Ribes-Koninckx, Paloma Jara, Deborah A. Neigut, Lucia Zancan, Zachery Goodman, Hanzhe Zheng, Bessie Hunter, Ulrike Kullmer, Pierre Broué |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Genotype Hepatitis C virus Hepacivirus Interferon alpha-2 medicine.disease_cause Antiviral Agents Polyethylene Glycols chemistry.chemical_compound Child Development Pegylated interferon Internal medicine Drug Resistance Viral Ribavirin medicine Humans Child Adverse effect Hepatology business.industry Body Weight Interferon-alpha Hepatitis C Hepatitis C Chronic Viral Load medicine.disease Body Height Recombinant Proteins Treatment Outcome chemistry Child Preschool Immunology Peginterferon alfa-2b Drug Therapy Combination Female Viral hepatitis business Viral load medicine.drug |
| Zdroj: | Journal of Hepatology. 52:501-507 |
| ISSN: | 0168-8278 |
| Popis: | Pegylated interferon (PEG-IFN) alfa-2b plus ribavirin (RBV) is the standard of care for adults with chronic hepatitis C but was not approved for the treatment of children at the time of this study. The aim of this study was to evaluate the efficacy and safety of PEG-IFN alfa-2b plus RBV in children.Children and adolescents ages 3-17 years were treated with PEG-IFN alfa-2b (60microg/m(2)/week) plus RBV (15mg/kg/day). The duration of therapy was 24 weeks for genotype (G) 2 and G3 patients with low viral load (600,000IU/ml) and 48 weeks for G1, G4, and G3 with high viral load (or=600,000IU/ml). The primary end point was sustained virologic response (SVR), defined as undetectable hepatitis C virus (HCV) RNA 24 weeks after completion of therapy.SVR was attained by 70 (65%) children. Genotype was the main predictor of response: G1, 53%; G2/3, 93%; G4, 80%. SVRs were similar in younger and older children. Baseline viral load was the main predictor of response in the G1 cohort. No new safety signals were identified, and adverse events (AEs) were generally mild or moderate in severity. Dose was modified because of AEs in 25% of children; 1 child discontinued because of an AE (thrombocytopenia). No serious AEs related to study drugs were reported.Therapy with PEG-IFN alfa-2b plus RBV in children and adolescents with chronic hepatitis C offers favorable efficacy, reduced injection frequency, and an acceptable safety profile. |
| Databáze: | OpenAIRE |
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