The use of adjuvant high-dose-rate breast brachytherapy in patients with collagen vascular disease: A collaborative experience
| Autor: | David E. Wazer, S. Eric Olyejar, Jennifer L. Harper, Raul G. Zunzunegui, Anthony E. Dragun |
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| Rok vydání: | 2011 |
| Předmět: |
Skin erythema
medicine.medical_specialty medicine.medical_treatment Brachytherapy Breast Neoplasms Breast cancer medicine Humans Radiology Nuclear Medicine and imaging Connective Tissue Diseases Aged Wound dehiscence business.industry Cosmesis Radiotherapy Dosage Middle Aged medicine.disease United States High-Dose Rate Brachytherapy Surgery Radiation therapy Treatment Outcome Oncology Seroma Female Radiotherapy Adjuvant Dose Fractionation Radiation business |
| Zdroj: | Brachytherapy. 10:121-127 |
| ISSN: | 1538-4721 |
| DOI: | 10.1016/j.brachy.2010.05.001 |
| Popis: | Purpose To analyze toxicity and cosmesis in patients with collagen vascular disease (CVD) treated with accelerated partial breast irradiation (APBI) via high-dose-rate (HDR) brachytherapy. Methods and Materials This is a pooled analysis of patients with early stage and in situ breast cancer with CVD treated with adjuvant multicatheter or balloon brachytherapy. Physicians at multiple institutions were asked to review their experience and report data regarding toxicity and cosmesis in patients with CVD. All patients fit American Society of Breast Surgeons recommendations for APBI and were treated with HDR brachytherapy with ≥3 months followup. Results Nine cases from five institutions are the subject of this analysis. The median patient age was 54 years and median followup was 31 months. All patients had documented history and active signs/symptoms of rheumatoid arthritis, systemic lupus erythematosis, psoriatic arthritis, or scleroderma. All patients had received medical therapy for CVD in the past, and 78% were under active treatment at the time of brachytherapy. All the patients were treated with multicatheter or balloon (MammoSite [Hologic, Inc., Marlboro, MA], MammoSite ML [Hologic, Inc., Marlboro, MA], or Contura [Senorx, Irvine, CA]) brachytherapy with a median volume of 45.5 cc and a median skin distance of 7.5 mm. Acute toxicity included Grade 1 skin erythema (5) and catheter-site wound dehiscence (1). Late toxicity included seroma (5), induration (5), pain (2), telangectasia (2), and superficial infection (1). Cosmesis was excellent or good for all the patients. Conclusions Women with CVD have a toxicity and cosmesis profile consistent with other APBI series. Although confirmatory data is needed, it may not be necessary to exclude these patients from clinical trials of APBI. |
| Databáze: | OpenAIRE |
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