CSF1 Receptor Targeting in Prostate Cancer Reverses Macrophage-Mediated Resistance to Androgen Blockade Therapy
| Autor: | Louis Lacombe, Gideon Bollag, James L. Sung, Ziyue Karen Jiang, Yves Fradet, Clara E. Magyar, Jemima Escamilla, Shiruyeh Schokrpur, Michael E. Jung, Gang Deng, Lily Wu, Connie Y Liu, Jingying Xu, Saul J. Priceman, Brian L. West, Diana Moughon, Jiaoti Huang, Frédéric Pouliot |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Urologic Diseases Cancer Research Carcinogenesis medicine.drug_class Angiogenesis Cells Oncology and Carcinogenesis Drug Resistance Receptor Macrophage Colony-Stimulating Factor Pharmacology medicine.disease_cause Article Mice Paracrine signalling Prostate cancer stomatognathic system medicine Animals Humans 2.1 Biological and endogenous factors Oncology & Carcinogenesis Aetiology Receptor Cells Cultured Cancer Cultured business.industry Macrophages Macrophage Colony-Stimulating Factor Prostate Cancer Prostatic Neoplasms Androgen Antagonists Androgen medicine.disease Blockade Oncology Drug Resistance Neoplasm Neoplasm Tumor promotion business |
| Zdroj: | Cancer research, vol 75, iss 6 Escamilla, J; Schokrpur, S; Liu, C; Priceman, SJ; Moughon, D; Jiang, Z; et al.(2015). CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy. Cancer Research, 75(6), 950-962. doi: 10.1158/0008-5472.CAN-14-0992. UCLA: Retrieved from: http://www.escholarship.org/uc/item/16x1m52m |
| ISSN: | 1538-7445 0008-5472 |
| Popis: | Growing evidence suggests that tumor-associated macrophages (TAM) promote cancer progression and therapeutic resistance by enhancing angiogenesis, matrix-remodeling, and immunosuppression. In this study, prostate cancer under androgen blockade therapy (ABT) was investigated, demonstrating that TAMs contribute to prostate cancer disease recurrence through paracrine signaling processes. ABT induced the tumor cells to express macrophage colony-stimulating factor 1 (M-CSF1 or CSF1) and other cytokines that recruit and modulate macrophages, causing a significant increase in TAM infiltration. Inhibitors of CSF1 signaling through its receptor, CSF1R, were tested in combination with ABT, demonstrating that blockade of TAM influx in this setting disrupts tumor promotion and sustains a more durable therapeutic response compared with ABT alone. Cancer Res; 75(6); 950–62. ©2015 AACR. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|