Cytokinesis block micronucleus assay in human lymphocytes after exposure to Ru(III) thiosemicarbazone complexes in vitro
| Autor: | Elma Šabanović, Sanja Grgurić-Šipka, Milka Jadranin, Vele Tešević, Miroslava Stanković, N. Ljubijankić, Sabina Begić |
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| Rok vydání: | 2018 |
| Předmět: |
CBMN assay
Ruthenium(III) complexes Thiosemycarbazone General Chemical Engineering General Chemistry medicine.disease_cause Biochemistry Molecular biology In vitro chemistry.chemical_compound General Energy chemistry Micronucleus Block (telecommunications) Micronucleus test medicine Chromosome aberrations General Pharmacology Toxicology and Pharmaceutics Genotoxicity Semicarbazone Cytokinesis |
| Zdroj: | Rasayan Journal of Chemistry |
| Popis: | This study evaluates the genotoxic potential of two Ru(III) complexes with thiosemicarbazone based ligands. The complexes were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using the cytokinesis block micronucleus (CBMN) assay at concentrations 1.5; 3.7 and 7.4 μg/mL. The cell culture treated with the tested complexes, at 3.7 μg/mL concentration, decreased a frequency of micronucleus for 37% and 32%, when compared with the control cell cultures. At concentration of 7.4 (1.5) μg/mL of this complexes exhibited slightly lower effect of micronucleus for 30% (35%) and 27% (29%), when compared with the control cell cultures. © RASĀYAN. All rights reserved. |
| Databáze: | OpenAIRE |
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