Outbreak of Pichia anomala Infection in the Pediatric Service of a Tertiary-Care Center in Northern India
| Autor: | S. M. Bose, Amitava Chakrabarti, S. Gopalan, Sunit Singhi, Anil Narang, R. Batra, K. L. N. Rao, Kartar Singh, Vishali Gupta, M. M. McNeil, Aditya K. Gupta, Sushmita Das, Pallab Ray |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Microbiology (medical) Pediatrics medicine.medical_specialty Antifungal Agents Pichia anomala India Infant Premature Diseases Microbial Sensitivity Tests Mycology Pichia Disease Outbreaks Risk Factors Intensive care Humans Medicine Anomala Fungemia Skin Cross Infection biology business.industry Infant Newborn Infant Outbreak Gestational age Hand medicine.disease biology.organism_classification Hospitals Low birth weight Carriage Mycoses Case-Control Studies Female medicine.symptom business Infant Premature |
| Zdroj: | Journal of Clinical Microbiology. 39:1702-1706 |
| ISSN: | 1098-660X 0095-1137 |
| Popis: | An outbreak of nosocomial fungemia due to the unusual yeast, Pichia anomala occurred in the pediatric wards of our hospital over a period of 23 months (April 1996 to February 1998). A total of 379 neonates and children (4.2% admissions) were infected. The probable index case was admitted to the pediatric emergency ward, with subsequent transmission to the premature nursery, pediatric intensive care units, and other children wards. Carriage on the hands of health care personnel was likely to be responsible for dissemination of the fungus. The outbreak could only be controlled after a health education campaign to improve hand-washing practices was instituted and after nystatin-fluconazole prophylaxis to all premature neonates and high-risk infants was introduced. In a case-control study, we identified a lower gestational age, a very low birth weight (P. anomala fungemia in premature neonates. We conducted a culture prevalence survey of 50 consecutive premature neonates and found that 28% were colonized with P. anomala at a skin or mucosal site on the date of delivery and that 20% of these neonates subsequently developed P. anomala fungemia. We performed multilocus enzyme electrophoresis on 40 P. anomala outbreak isolates (including patient and health care workers' hand isolates), and the results suggested that these isolates were identical. Our study highlights the importance of P. anomala as an emerging nosocomial fungal pathogen. |
| Databáze: | OpenAIRE |
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