Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)
| Autor: | M. Taufer, Maria Fernanda Lima-Costa, A.K. Fuzikawa, Emílio Hideyuki Moriguchi, Sérgio V. Peixoto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Apolipoprotein E Gerontology medicine.medical_specialty Genotype Physiology Immunology Biophysics Biochemistry Cohort Studies chemistry.chemical_compound Apolipoproteins E Gene Frequency Polymorphism (computer science) Internal medicine Prevalence Humans Medicine Low-density lipoprotein cholesterol General Pharmacology Toxicology and Pharmaceutics Allele frequency lcsh:QH301-705.5 Triglycerides Aged Aged 80 and over Creatinine lcsh:R5-920 Polymorphism Genetic business.industry General Neuroscience Cholesterol HDL Confounding Confounding Factors Epidemiologic Cholesterol LDL Cell Biology General Medicine Middle Aged Blood pressure Lipid metabolism chemistry lcsh:Biology (General) Hypertension Female business lcsh:Medicine (General) Brazil Cohort study |
| Zdroj: | Brazilian Journal of Medical and Biological Research v.41 n.2 2008 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research v.41 n.7 2008 Brazilian Journal of Medical and Biological Research, Vol 41, Iss 7, Pp 640-641 (2008) Brazilian Journal of Medical and Biological Research, Vol 41, Iss 7, Pp 640-641 Brazilian Journal of Medical and Biological Research, Vol 41, Iss 2, Pp 89-94 Brazilian Journal of Medical and Biological Research, Volume: 41, Issue: 7, Pages: 640-641, Published: JUL 2008 Brazilian Journal of Medical and Biological Research, Volume: 41, Issue: 2, Pages: 89-94, Published: FEB 2008 Brazilian Journal of Medical and Biological Research, Vol 41, Iss 2, Pp 89-94 (2008) |
| Popis: | Apolipoprotein E (ApoE) polymorphism influences lipid metabolism, but its association with arterial hypertension is controversial. The objective of this study was to examine the association between ApoE polymorphism and prevalent hypertension in a large unselected population of older adults. Participants from the baseline of the Bambuí Health Aging Study whose ApoE genes had been genotyped were selected for this study (N = 1406, aged 60-95 years). These subjects represented 80.7% of the total elderly residents in Bambuí city, MG, Brazil. Hypertension was defined as a systolic blood pressureor =140 mmHg and/or a diastolic blood pressureor =90 mmHg, or the use of anti-hypertensive medication. The exposure variable was the ApoE genotype as follows: epsilon3 carriers, epsilon3epsilon3; epsilon2 carriers, epsilon2epsilon2 or epsilon2epsilon3, and epsilon4 carriers, epsilon3epsilon4 or epsilon4epsilon4. Potential confounding variables were age, gender, traditional cardiovascular risk factors, uric acid, and creatinine levels. The prevalence of hypertension was 61.3%. Compared with the epsilon3 homozygotes, neither the epsilon2 nor the epsilon4 carrier status was associated with hypertension (adjusted prevalence ratios = 0.94, 95%CI = 0.83-1.07 and 0.98, 0.89-1.07, respectively). On the other hand, the epsilon2 allele carriers had lower LDL cholesterol levels (P0.001) and the epsilon4 carriers had higher LDL cholesterol levels (P = 0.036). This study provides epidemiologic evidence that the ApoE genotype is not associated with prevalent hypertension in old age. |
| Databáze: | OpenAIRE |
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