Initiation and dynamics of a spiral wave around an ionic heterogeneity in a model for human cardiac tissue
| Autor: | Alexander V. Panfilov, Peter Dawyndt, Arne Defauw |
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| Rok vydání: | 2013 |
| Předmět: |
TORSADE-DE-POINTES
Quantitative Biology::Tissues and Organs Physics::Medical Physics Transmural dispersion LONG-QT SYNDROME CONDUCTION BLOCK Electrocardiography BETA-ADRENERGIC AGONISTS ISOLATED RABBIT HEART Beta-Adrenergic Agonist otorhinolaryngologic diseases Humans ONE-DIMENSIONAL CABLE VULNERABLE WINDOW Bifurcation Spiral Physics ACTION-POTENTIAL DURATION Myocardium Dynamics (mechanics) Models Cardiovascular Biology and Life Sciences Heart Mechanics Spiral wave Action potential duration TRANSMURAL DISPERSION HUMAN VENTRICULAR TISSUE |
| Zdroj: | PHYSICAL REVIEW E |
| ISSN: | 1550-2376 1539-3755 |
| DOI: | 10.1103/physreve.88.062703 |
| Popis: | In relation to cardiac arrhythmias, heterogeneity of cardiac tissue is one of the most important factors underlying the onset of spiral waves and determining their type. In this paper, we numerically model heterogeneity of realistic size and value and study formation and dynamics of spiral waves around such heterogeneity. We find that the only sustained pattern obtained is a single spiral wave anchored around the heterogeneity. Dynamics of an anchored spiral wave depend on the extent of heterogeneity, and for certain heterogeneity size, we find abrupt regional increase in the period of excitation occurring as a bifurcation. We study factors determining spatial distribution of excitation periods of anchored spiral waves and discuss consequences of such dynamics for cardiac arrhythmias and possibilities for experimental testings of our predictions. |
| Databáze: | OpenAIRE |
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