Reproducibility of Growth Hormone Testing Procedures: A Comparison between 24-hour Integrated Concentration and Pharmacological Stimulation
| Autor: | Avinoam Kowarski, Zvi Zadik, Zvi Gilula, Stuart A. Chalew |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Arginine Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Growth hormone Biochemistry Clonidine Endocrinology Internal medicine medicine Humans Insulin Child Growth Disorders Reproducibility business.industry Biochemistry (medical) Pharmacological stimulation Reproducibility of Results Growth hormone secretion Circadian Rhythm Somatropin Child Preschool Growth Hormone Female business medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 71:1127-1130 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | The purpose of this study was to compare the reproducibility of two approaches to the evaluation of GH secretion: the integrated concentration of GH (IC-GH), a physiological test of GH secretion, and pharmacological stimulation tests. IC-GH was determined in 40 poorly growing children twice within 4 weeks. The first and second IC-GH were highly correlated r = 0.859, P less than 0.001. One hundred and thirteen poorly growing children underwent pharmacological GH stimulation tests twice within 6 weeks. A moderate correlation was found between the first and second pharmacological test r = 0.524, P less than 0.01. Among the three pharmacological stimuli studied, clonidine (n = 81) had the highest reproducibility followed by arginine (n = 20), and insulin (n = 12). We conclude that IC-GH is more consistently reproducible than the GH response to repeated pharmacological stimulation. |
| Databáze: | OpenAIRE |
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