The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review
| Autor: | Tahmineh Mokhtari, Xia-Qing Wang, Li Hu, Lupeng Yue, Yu-Xuan Zeng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Analgesic
Receptors Opioid mu Pain Neurosciences. Biological psychiatry. Neuropsychiatry Review Article Nucleus accumbens Periaqueductal gray Nucleus Accumbens 03 medical and health sciences 0302 clinical medicine Dopamine receptor D2 medicine Animals Humans Periaqueductal Gray Receptor Pain Measurement 030304 developmental biology Analgesics 0303 health sciences Receptors Dopamine D2 business.industry Chronic pain Drug Tolerance medicine.disease Neurology Dopamine receptor Hyperalgesia Neurology (clinical) medicine.symptom business Neuroscience 030217 neurology & neurosurgery RC321-571 |
| Zdroj: | Neural Plasticity Neural Plasticity, Vol 2021 (2021) |
| ISSN: | 1687-5443 2090-5904 |
| DOI: | 10.1155/2021/6682275 |
| Popis: | Chronic pain is considered an economic burden on society as it often results in disability, job loss, and early retirement. Opioids are the most common analgesics prescribed for the management of moderate to severe pain. However, chronic exposure to these drugs can result in opioid tolerance and opioid-induced hyperalgesia. On pain modulation strategies, exploiting the multitarget drugs with the ability of the superadditive or synergistic interactions attracts more attention. In the present report, we have reviewed the analgesic effects of different dopamine receptors, particularly D1 and D2 receptors, in different regions of the central nervous system, including the spinal cord, striatum, nucleus accumbens (NAc), and periaqueductal gray (PAG). According to the evidence, these regions are not only involved in pain modulation but also express a high density of DA receptors. The findings can be categorized as follows: (1) D2-like receptors may exert a higher analgesic potency, but D1-like receptors act in different manners across several mechanisms in the mentioned regions; (2) in the spinal cord and striatum, antinociception of DA is mainly mediated by D2-like receptors, while in the NAc and PAG, both D1- and D2-like receptors are involved as analgesic targets; and (3) D2-like receptor agonists can act as adjuvants of μ-opioid receptor agonists to potentiate analgesic effects and provide a better approach to pain relief. |
| Databáze: | OpenAIRE |
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