Delayed diagnosis of sporadic Creutzfeldt-Jakob disease in a patient with schizophrenia
| Autor: | Mary Alice O'Dowd, David T. Chuang, Ariela Frieder, Sheryl R. Haut, Matthew S. Robbins |
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| Rok vydání: | 2011 |
| Předmět: |
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Myoclonus Pediatrics medicine.medical_specialty Psychosis Ataxia Delayed Diagnosis Hallucinations Akinetic mutism Creutzfeldt-Jakob Syndrome Diagnosis Differential Arts and Humanities (miscellaneous) Extrapyramidal symptoms Sleep Initiation and Maintenance Disorders medicine Humans Applied Psychology Depression (differential diagnoses) business.industry Cortical blindness Electroencephalography Middle Aged medicine.disease Magnetic Resonance Imaging nervous system diseases Psychiatry and Mental health Akinetic Mutism Alcoholism Schizophrenia Disease Progression Hemianopsia Schizophrenic Psychology medicine.symptom business |
| Zdroj: | Psychosomatics. 53(4) |
| ISSN: | 1545-7206 |
| Popis: | Human transmissible spongiform encephalopathies, also known as prion diseases, are caused by abnormal folding of normal prion proteins in the brain. Sporadic Creutzfeldt-Jakob Disease (sCJD), the most common prion disease, occurs at an annual rate of one in 1 million and often leads to a fatal outcome within a year. The mean age of onset is 55 to 75 years old. sCJD is a cause of rapidly progressive dementia but because of its rarity, may not be on the differential diagnosis in its earlier stages of manifestation, particularly if a patient lacks other neurological symptoms. Patients with sCJD often present with early cognitive and psychiatric manifestations, such as memory loss, irritability, depression, ataxia, extrapyramidal symptoms, and in rarer instances, psychosis. Later symptoms include myoclonus, cortical blindness, seizures, and in its final stage, akinetic mutism. We report a patient ultimately found to have sCJD whose presentation was initially mistaken for an exacerbation of his chronic schizophrenia, delaying his diagnosis. |
| Databáze: | OpenAIRE |
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