Viral metagenomics revealed novel betatorquevirus species in pediatric inpatients with encephalitis/meningoencephalitis from Ghana
Autor: | Benedikt Hogan, JuÌrgen May, Ellis Owusu-Dabo, Daniel Cadar, Nicole S. Struck, Yaw Adu-Sarkodie, Daniel Eibach, Jonas Schmidt-Chanasit, Doris Winter, Nimako Sarpong |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
0301 basic medicine Viral metagenomics lcsh:Medicine Anelloviridae Ghana Article Defective virus 03 medical and health sciences 0302 clinical medicine Meningoencephalitis Prevalence medicine Humans Human virome Child lcsh:Science Phylogeny Torque teno virus Inpatients Multidisciplinary Torque teno mini virus biology lcsh:R biology.organism_classification medicine.disease Virology DNA Virus Infections 030104 developmental biology Viral replication Child Preschool DNA Viral Encephalitis Female lcsh:Q Metagenomics 030217 neurology & neurosurgery |
Zdroj: | Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | The cause of acute encephalitis/meningoencephalitis in pediatric patients remains often unexplained despite extensive investigations for large panel of pathogens. To explore a possible viral implication, we investigated the virome of cerebrospinal fluid specimens of 70 febrile pediatric inpatients with clinical compatible encephalitis/meningoencephalitis. Using viral metagenomics, we detected and genetically characterized three novel human Torque teno mini virus (TTMV) species (TTMV-G1-3). Phylogenetically, TTMV-G1-3 clustered in three novel monophyletic lineages within genus Betatorquevirus of the Anelloviridae family. TTMV-G1-3 were highly prevalent in diseased children, but absent in the healthy cohort which may indicate an association of TTMV species with febrile illness. With 2/3 detected malaria co-infection, it remains unclear if these novel anellovirus species are causative agents or increase disease severity by interaction with malaria parasites. The presence of the viruses 28 days after initiating antimalarial and/or antibiotic treatment suggests a still active viral infection likely as effect of parasitic and/or bacterial co-infection that may have initiated a modulated immune system environment for viral replication or a defective virus clearance. This study increases the current knowledge on the genetic diversity of TTMV and strengthens that human anelloviruses can be considered as biomarkers for strong perturbations of the immune system in certain pathological conditions. |
Databáze: | OpenAIRE |
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