Brain Perfusion Mediates the Relationship Between miRNA Levels and Postural Control

Autor:	Barbara Knollmann-Ritschel, Anne J. Blood, Alexa E Walter, Yufen Chen, Semyon Slobounov, Khrystyna Stetsiv, Thomas M. Talavage, Sumra Bari, Hans C. Breiter, Manish Bhomia, Eric A. Nauman, Linda Papa, James L. Reilly, Jaroslaw Harezlak, Zoran Martinovich, Peter H. Seidenberg, Nicole L. Vike, Amy A. Herrold
Rok vydání:	2020
Předmět:	0301 basic medicine medicine.medical_specialty football athletes Perfusion scanning Inflammation postural control head acceleration events 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine General Environmental Science Balance (ability) biology business.industry Athletes Putamen regional cerebral blood flow biology.organism_classification Omics microRNAs 030104 developmental biology nervous system Cerebral blood flow Cardiology General Earth and Planetary Sciences Original Article medicine.symptom business Perfusion psychological phenomena and processes 030217 neurology & neurosurgery
Zdroj:	Cerebral Cortex Communications
ISSN:	2632-7376
DOI:	10.1093/texcom/tgaa078
Popis:	Transcriptomics, regional cerebral blood flow (rCBF), and a virtual reality-based spatial motor task were integrated using mediation analysis in a novel demonstration of “imaging omics.” Data collected in National Collegiate Athletic Association (NCAA) Division I football athletes cleared for play before in-season training showed significant relationships in 1) elevated levels of miR-30d and miR-92a to elevated putamen rCBF, 2) elevated putamen rCBF to compromised Balance scores, and 3) compromised Balance scores to elevated microRNA (miRNA) levels. rCBF acted as a consistent mediator variable (Sobel’s test P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c8c95710c7be5300f0ad612e9dd7e8 https://doi.org/10.1093/texcom/tgaa078 Zobrazit plný text záznamu