Occult Hepatitis B Virus Infection in Immunized Infants Born to Untreated and Tenofovir-Treated Highly Viremic Mothers
| Autor: | Hong-Yuan Hsu, Huey-Ling Chen, Jia-Feng Wu, Yen-Hsuan Ni, Kai-Chi Chang, Cheng-Lun Chiang, Chien-Nan Lee, Lu-Lu Zhao, Ming-Wei Lai, Shu-Chi Mu, Wan-Hsin Wen, Lung-Huang Lin, Mei-Hwei Chang, Shyu MK, Hwa HL, Su YN, Shih JC, Chao KH, Chiu YC, Liu CJ, Su TH, Chen DS, Chen SM, Lin CC, Lin PY, Yang WR, Hu JJ, Yang CK, Chang YK, Chen KH, Lin HH, Lin YH, Chen HJ, Pan HS, Lau BH, Lee CL, Cheng PJ, Chang YL, Chiueh HY, Wang TH, Hsu JJ, Lo LM, Hsieh CL, Cheng SW, Tsai MS, She BQ, Peng FS, Lin YC, Chen CP, Huang JP, Yeung CY |
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| Rok vydání: | 2020 |
| Předmět: |
HBsAg
Hepatitis B virus Tenofovir Mothers medicine.disease_cause Hepatitis b surface antigen 03 medical and health sciences 0302 clinical medicine Pregnancy Medicine Humans Hepatitis B Surface Antigens Hepatology business.industry Gastroenterology virus diseases Infant medicine.disease Hepatitis B Late pregnancy Virology Occult digestive system diseases Infectious Disease Transmission Vertical 030220 oncology & carcinogenesis DNA Viral 030211 gastroenterology & hepatology Female business medicine.drug |
| Zdroj: | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 19(7) |
| ISSN: | 1542-7714 |
| Popis: | Tenofovir disoproxil fumurate (TDF) therapy during late pregnancy in highly viremic mothers can reduce residual overt hepatitis B virus (HBV) infections of their infants that occur despite immunoprophylaxis.1,2 Occult HBV infection (OBI) has been defined as the presence of HBV DNA in liver or sera in subjects seronegative for hepatitis B surface antigen (HBsAg).3 OBI has been found in varying proportions of immunized infants born to HBsAg-positive mothers.4-6 We aimed to investigate the impact of maternal TDF therapy during pregnancy on vertically acquired OBI. |
| Databáze: | OpenAIRE |
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