Infantile acne as the initial sign of an adrenocortical tumor
| Autor: | Susan B. Mallory, Susan Schroeder Ellis, Margaret W. Mann |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Urology Dehydroepiandrosterone Dermatology chemistry.chemical_compound Dehydroepiandrosterone sulfate Internal medicine Acne Vulgaris medicine Humans Testosterone Infantile acne Acne Ultrasonography business.industry Adrenal cortex Virilization Infant medicine.disease Adrenal Cortex Neoplasms Treatment Outcome Endocrinology medicine.anatomical_structure chemistry Adrenocortical Adenoma medicine.symptom Tomography X-Ray Computed business Luteinizing hormone hormones hormone substitutes and hormone antagonists Hair Penis Hormone |
| Zdroj: | Journal of the American Academy of Dermatology. 56:S15-S18 |
| ISSN: | 0190-9622 |
| Popis: | A 23-month-old boy with persistent acne since 6 months of age had signs of virilization and accelerated growth. Hormone evaluation indicated increased levels of dehydroepiandrosterone (DHEA) and testosterone. Ultrasound and abdominal computed tomographic scan revealed a large adrenal mass consistent with an adrenocortical tumor. The patient underwent surgical excision of the well-encapsulated tumor with normalization of his hormones and no subsequent recurrence. Although rare, childhood adrenocortical tumors have a poor prognosis, with the majority of tumors having regional and metastatic disease. Because early diagnosis and complete surgical excision improve prognosis, children with refractory infantile acne should be evaluated for signs of virilization and accelerated growth. Laboratory evaluation should include luteinizing hormone, follicle-stimulating hormone, total and free testosterone cortisol, DHEA, and its sulfate (DHEA-S). Elevated levels of DHEA and DHEA-S should prompt an aggressive diagnostic evaluation for an adrenocortical tumor. |
| Databáze: | OpenAIRE |
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