EARLY HYPERBARIC OXYGEN THERAPY FOR REDUCING RADIOTHERAPY SIDE EFFECTS: EARLY RESULTS OF A RANDOMIZED TRIAL IN OROPHARYNGEAL AND NASOPHARYNGEAL CANCER
| Autor: | Wouter Sterk, Michiel P.C. van der Huls, David N. Teguh, Peter W.J. Voet, Peter C. Levendag, Antoine G. Dumans, Peter van Rooij, Maarten F. de Boer, Paul I.M. Schmitz, Inge Noever, Henrie van der Est |
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| Přispěvatelé: | Radiotherapy, Erasmus MC other, Oral and Maxillofacial Surgery, Otorhinolaryngology and Head and Neck Surgery, Hematology |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Time Factors medicine.medical_treatment Nasopharyngeal neoplasm Trismus Xerostomia law.invention Quality of life Randomized controlled trial Swallowing stomatognathic system SDG 3 - Good Health and Well-being law medicine Humans Radiology Nuclear Medicine and imaging Radiation Injuries Hyperbaric Oxygenation Radiation business.industry Head and neck cancer Nasopharyngeal Neoplasms Radiotherapy Dosage medicine.disease humanities Surgery Radiation therapy Oropharyngeal Neoplasms Oncology Carcinoma Squamous Cell Quality of Life Tonsillar fossa Regression Analysis Female medicine.symptom business Deglutition Disorders |
| Zdroj: | International Journal of Radiation Oncology Biology Physics, 75(3), 711-716. Elsevier Inc. |
| ISSN: | 0360-3016 |
| Popis: | Purpose: Comparison of quality of life (QoL) and side effects in a randomized trial for early hyperbaric oxygen therapy (HBOT) after radiotherapy (RT). Methods and Materials: From 2006, 19 patients with tumor originating from the tonsillar fossa and/or soft palate (15), base of tongue (1), and nasopharynx (3) were randomized to receive HBOT or not. HBOT consisted of 30 sessions at 2.5 ATA (15 msw) with oxygen breathing for 90 min daily, 5 days per week, applied shortly after the RT treatment was completed. As of 2005, all patients received validated questionnaires (i.e., the European Organization for Research and Treatment of Cancer [EORTC] QLQ-C30, EORTC QLQ Head and Neck Cancer Module (H&N35), Performance Status Scale): before treatment; at the start of RT treatment; after 46 Gy; at the end of RT treatment; and 2, 4, and 6 weeks and 3, 6, 12, and 18 months after follow-up. Results: On all QoL items, better scores were obtained in patients treated with hyperbaric oxygen. The difference between HBOT vs. non-HBOT was significant for all parameters: EORTC H&N35 Swallowing (p = 0.011), EORTC H&N35 Dry Mouth (p = 0.009), EORTC H&N35 Sticky Saliva (p = 0.01), PSS Eating in Public (p 0.027), and Pain in Mouth (visual analogue scale; p < 0.0001). Conclusions: Patients randomized for receiving hyperbaric oxygen after the RT had better QoL scores for swallowing, sticky saliva, xerostomia, and pain in mouth. (C) 2009 Elsevier Inc. |
| Databáze: | OpenAIRE |
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